ORIGINAL RESEARCH article
Front. Tuberc.
Sec. Epidemiology of Tuberculosis
Volume 3 - 2025 | doi: 10.3389/ftubr.2025.1608364
This article is part of the Research TopicCommunity Insights in Tuberculosis EpidemiologyView all 3 articles
RISK FACTORS ASSOCIATED WITH MULTIDRUG-RESISTANT PULMONARY TUBERCULOSIS IN PATIENTS OVER 15 YEARS OLD: A RETROSPECTIVE CASE-CONTROL STUDY
Provisionally accepted
- 1Faculty of Medicine, Agostinho Neto University, Luanda, Angola
- 2Clínica Sagrada Esperança, Luanda, Angola
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Introduction: Multidrug-Resistant Pulmonary Tuberculosis (MDR-TB) represents a serious public health problem, hindering disease control and increasing morbidity and mortality. This study aimed to identify risk factors associated with MDR-TB in patients over 15 years old at the Sanatorium Hospital of Luanda during the period 2015-2016.Methods: A retrospective case-control study (1:1) was conducted with 500 participants, including 250 cases (MDR-TB) and 250 controls (drug-sensitive TB). Data were obtained from clinical records and analyzed using logistic regression in Epi-Info 7.2.1.0 software, considering a significance level of p<0.05.Results: MDR-TB was more prevalent in men (61.6%), in the age group 20-29 years (36.8%), and among employed individuals (73.2%). The associated risk factors were irregular medication adherence (odds ratio OR=12.3; p<0.001), previous TB treatment (OR=9.0; p<0.001), contact with an MDR-TB patient (OR=4.1; p<0.001), and lower educational level (OR=2.1; p=0.03).Irregular adherence to treatment and a history of previous TB were the main factors associated with MDR-TB, reinforcing the need for effective strategies to ensure treatment followup.
Keywords: Multidrug-resistant pulmonary tuberculosis, Risk factors, irregular treatment, Angola, Epidemiology
Received: 08 Apr 2025; Accepted: 26 Jun 2025.
Copyright: © 2025 Bambi Receado, Solary, Catumbela and de Sousa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Odete da Conceição Bambi Receado, Faculty of Medicine, Agostinho Neto University, Luanda, Angola
Emanuel Catumbela, Faculty of Medicine, Agostinho Neto University, Luanda, Angola
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