REVIEW article
Front. Tuberc.
Sec. Diagnosis of Tuberculosis
Volume 3 - 2025 | doi: 10.3389/ftubr.2025.1608780
The value of LAM and LprG in extracellular vesicles in the diagnostic and therapeutic field of renal tuberculosis
Provisionally accepted
- Guizhou Medical University, Guiyang, China
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Extracellular vesicles have been a hot research topic in recent years, and the diagnostic and therapeutic value of LprG and LAM, two key markers present in extracellular vesicles secreted by Mycobacterium tuberculosis or Mycobacterium tuberculosis-infected immune cells, in tuberculosis, has been widely emphasized in recent years. Genitourinary tuberculosis is a common form of extrapulmonary tuberculosis, and renal tuberculosis accounts for more than 20% of patients with Genitourinary tuberculosis. In this paper, we summarize the findings and research ideas of LprG and LAM in the diagnosis and treatment of renal tuberculosis in recent years and conclude that LprG and LAM have their unique diagnostic value in the intrapulmonary and extrapulmonary fields and can be used as a new potential idea for vaccine or immunotherapy in the future for research.
Keywords: extracellular vesicles, Mycobacterium tuberculosis, Renal tuberculosis, LAM, LprG, Diagnosis and treatment
Received: 09 Apr 2025; Accepted: 23 Jun 2025.
Copyright: © 2025 Peng, Li, Jin and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qiang Wang, Guizhou Medical University, Guiyang, China
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