MINI REVIEW article

Front. Tuberc.

Sec. Diagnosis of Tuberculosis

Volume 3 - 2025 | doi: 10.3389/ftubr.2025.1623373

Editorial: Discerning active tuberculosis from latent infection

Provisionally accepted
Pere-Joan CardonaPere-Joan Cardona1,2,3,4*Synne JenumSynne Jenum5Novel N ChegouNovel N Chegou6
  • 1Microbiology Department, Northern Metropolitan Clinical Laboratory, Hospital Universitari “Germans Trias i Pujol”, Catalonia., Badalona, Spain
  • 2Experimental Tuberculosis Unit, Germans Trias i Pujol Research Institute (IGTP),Catalonia,, Badalona, Spain
  • 3Genetics and Microbiology Department,Autonomous University of Barcelona, Catalonia,, Cerdanyola del Vallès, Spain
  • 4Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain
  • 5Department of Infectious Diseases, Oslo University Hospital., Oslo, Norway
  • 6South African Medical Research Council Centre for Tuberculosis Research, Division of Immunology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa

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Figure 1. The lung microenvironment: where progression begins. The current challenge in identifying a predictive biosignature for tuberculosis (TB) progression in individuals infected with Mycobacterium tuberculosis, represented with the tube with a positive outcome. Paediatric TB presenting as a Ghon nodule (A); non-progressive paediatric infection (B); non-progressive adult infection with multiple infectious foci in the basal lobes (C); TB in adults following progression of a single infectious focus in the upper lobe (D) (created by BioRender.com).

Keywords: TB spectrum, lung microenvironment, precision prevention, Tuberculosis, upper lobes, blood biosignatures, latent tuberculosis infection

Received: 05 May 2025; Accepted: 27 May 2025.

Copyright: © 2025 Cardona, Jenum and Chegou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Pere-Joan Cardona, Microbiology Department, Northern Metropolitan Clinical Laboratory, Hospital Universitari “Germans Trias i Pujol”, Catalonia., Badalona, Spain

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material