REVIEW article
Front. Vet. Sci.
Sec. Zoological Medicine
This article is part of the Research TopicEndometrial Health and Disease: From Molecular Insights to Clinical AdvancesView all articles
The pig as a medical model for Gynecological diseases:An Applied Perspective
Provisionally accepted
- 1Changchun University of Chinese Medicine, Changchun, China
- 2China Academy of Chinese Medical Sciences, Beijing, China
- 3Cangzhou Integrated Traditional Chinese and Western Medicine Hospital, Cangzhou, China
- 4The Third Affiliated Clinical Hospital of Changchun University of Chinese Medicine, Changchun, China
- 5Tongde Hospital of Zhejiang Province, Hangzhou, China
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Gynecological diseases pose substantial risks to female reproductive health and overall wellbeing. To improve disease prevention and treatment, researchers continue to develop experimental models that faithfully replicate key features of the female reproductive system. Porcine models have gained increasing attention in gynecological research due to their substantial similarities to humans in anatomical structure, physiological function, and pathological processes. This review aims to evaluate the practical applications of porcine models for investigating gynecological disorders. We examine the use of porcine models in studying common gynecological diseases such as endometritis, infertility, and ovarian cancer, analyze their advantages and limitations, and discuss their role in genetic engineering applications. Notably, porcine models have facilitated key advances in gynecological research, including elucidating neuropeptide-mediated uterine dysmotility in endometritis, refining surgical techniques for uterine transplantation and vaginoplasty in infertility management, and evaluating dihydroartemisinin as a potential therapeutic agent for ovarian cancer. This analysis aims to characterize the distinctive features of porcine models for gynecological research, thereby facilitating the selection of optimal animal models for future preclinical studies.
Keywords: pigs, gynecological diseases, large animal models, ovarian cancer, Genetic Engineering
Received: 17 Jul 2025; Accepted: 02 Dec 2025.
Copyright: © 2025 Zhao, Zhao, Zhang, Liu, Deng and Qi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Guangju Qi
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