ORIGINAL RESEARCH article
Front. Vet. Sci.
Sec. Animal Nutrition and Metabolism
Ginseng Polysaccharides Ameliorate DSS-Induced Inflammatory Bowel Disease by Regulating Gut Microbiota in Dogs
Provisionally accepted
- 1College of Police Dog Technology, Criminal Investigation Police University of China, Shenyang, China
- 2College of Animal Science and Technology, College of Veterinary Medicine, Jilin Agricultural University, Changchun, China
- 3Animal Nutrition Institute of Sichuan Agricultural University, Chengdu, China
- 4Jilin University College of Veterinary Medicine, Changchun, China
- 5Chinese Academy of Agricultural Sciences Institute of Special Animal and Plant Sciences, Changchun, China
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Inflammatory bowel disease (IBD) is a common chronic gastrointestinal disorder in dogs that seriously affects health and quality of life. This study evaluated the effects of ginseng polysaccharides on dextran sodium sulfate (DSS)-induced IBD in dogs, with emphasis on clinical symptoms, serum parameters, and gut microbiota. Our findings revealed that treatment with ginseng polysaccharides alleviated clinical symptoms, improved colonic histopathology, and partially restored serum biochemical changes, including a significant reduction in C-reactive protein. Microbiota analysis showed increased alpha diversity and recovery of community composition, with enrichment of beneficial genera such as Bacteroides, Megamonas, and Fusobacterium, and reduction of Campylobacter. Functional prediction indicated that ginseng polysaccharides reversed DSS-associated suppression of carbohydrate metabolism pathways. These findings suggest that ginseng polysaccharides mitigate DSS-induced IBD in dogs by modulating inflammation and gut microbiota composition, supporting their potential as a natural therapeutic candidate for canine IBD.
Keywords: Ginseng polysaccharide, Gut Microbiota, inflammatory bowel disease, Serum parameters, short-chain fatty acids
Received: 19 Sep 2025; Accepted: 15 Dec 2025.
Copyright: © 2025 Xie, Li, Mao, Han, Zhang, Liu, Liu, Zhao and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Weigang Zhao
Chao Xu
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