CASE REPORT article
Front. Vet. Sci.
Sec. Oncology in Veterinary Medicine
Case report: Primary intestinal histiocytic sarcoma in a cat
Provisionally accepted
- AniCura Ars Veterinaria, Barcelona, Spain
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Histiocytic sarcoma (HS) is a rare and aggressive tumor in cats, usually presenting in a multicentric or disseminated form, with gastrointestinal involvement mainly reported as part of a metastatic disease. This report describes the first documented case of a primary intestinal HS in an 11-year-old male neutered domestic short-haired cat, presenting with acute gastrointestinal signs. Diagnostic workup included ultrasonography, cytology, histopathology, and immunohistochemistry (IHC), which confirmed a histiocytic origin through Iba-1, CD204 and MHC-II positivity and MUM1, CD117 and Desmin negativity. The patient underwent surgical excision via enterectomy, followed by adjuvant lomustine chemotherapy, achieving complete remission. Despite transient chemotherapy-induced myelosuppression, the cat remains alive and disease-free 2 years after diagnosis. This case highlights the importance of combining imaging, histopathology, and IHC when diagnosing feline intestinal masses.
Keywords: Feline oncology, Histiocytic Sarcoma, Immunohistochemistry, Intestinal neoplasia, lomustine chemotherapy
Received: 17 Oct 2025; Accepted: 03 Dec 2025.
Copyright: © 2025 Pérez, Clanxet, Clemente-Vicario, Puig and Feo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Andrea Pérez
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