EDITORIAL article
Front. Vet. Sci.
Sec. Veterinary Clinical, Anatomical, and Comparative Pathology
This article is part of the Research TopicAdvances in non-clinical and translational studies: cutting-edge study designs, special technologies, routine pitfalls, background findings and control data.View all 9 articles
Editorial: Advances in non-clinical and translational studies: cutting-edge study designs, special technologies, routine pitfalls, background findings, and control data
Provisionally accepted
- 1AnaPath Services GmbH, Liestal, Switzerland
- 2University of South Florida, Tampa, United States
- 3Fraunhofer-Institut fur Toxikologie und Experimentelle Medizin ITEM, Hanover, Germany
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Non-clinical and translational research sits at a difficult crossroads as it must answer increasingly subtle questions about efficacy and safety while honoring 3R commitments and high animal welfare standards. As designs grow more complex and readouts more multidimensional, interpretation ─not just measurement─ can become the rate-limiting step. This research topic tackles that interpretive gap head-on. Across eight publications, it delivers tools, lexicons, and decision frameworks which render complex studies more intelligible, reproducible, and humane.Starting with a pragmatic example, mechanistic imaging often fails, not for lack of sensitivity but for lack of simultaneity across tissue layers.
Keywords: laboratory animals, translational medicine, non-clinical studies, new alternativemethodologies, enhanced toxicology interpretation, background findings
Received: 11 Nov 2025; Accepted: 02 Dec 2025.
Copyright: © 2025 Weber, Hayes, Schaudien and De Miguel. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ricardo De Miguel
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.