ORIGINAL RESEARCH article
Front. Vet. Sci.
Sec. Veterinary Emergency and Critical Care Medicine
Influence of Etamsylate on Coagulation Parameters in Dogs
Leonie Wörz
René Dörfelt
Katrin Hartmann
Vera Geisen
Ludwig Maximilian University of Munich, Munich, Germany
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Abstract
The mechanism of etamsylate on capillary bleeding and its influence on hemostasis is not yet fully understood. This study aims to evaluate the effects of etamsylate on thromboelastographic parameters, platelet count, clotting times and fibrinogen, and its adverse events in dogs. Dogs included in this prospective, non-randomized, single-arm interventional study with comparative analysis between clinical groups were divided into dogs without coagulopathies undergoing procedures with high risk of bleeding (n = 10), dogs with bleeding due to trauma or coagulopathy (n = 10), and thrombocytopenic dogs with a platelet count <80 x 109/l (n = 10). Dogs that had previously received drugs or fluids influencing hemostasis were excluded. Blood samples were collected for clotting times, platelet count, thromboelastography, and fibrinogen analysis before and 90 minutes after etamsylate administration (12.5 mg/kg IV). Thromboelastographic parameters, platelet count, clotting time, and fibrinogen concentrations did not change after treatment with etamsylate in the entire study population and in subgroup analyses. No adverse events of etamsylate were observed. In the present study, no effect of etamsylate on hemostasis in dogs could be detected using coagulation parameters. Further studies using methods that incorporate the function of the vascular endothelium are necessary.
Summary
Keywords
canine, Dicynone, Fibrinogen, Hemorrhage, Hemostasis, platelets, Thromboelastography, viscoelastic tests
Received
28 October 2025
Accepted
17 February 2026
Copyright
© 2026 Wörz, Dörfelt, Hartmann and Geisen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Vera Geisen
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