CASE REPORT article
Front. Vet. Sci.
Sec. Oncology in Veterinary Medicine
This article is part of the Research TopicExploring electrochemotherapy as a promising intervention in veterinary cancer careView all articles
Endoscopic-Guided Electrochemotherapy combined with Metronomic Chemotherapy for the treatment of Nasal Tumors in Dogs
Provisionally accepted
Giulia Maggi1,2*
Alfredo Dentini2Giuseppe Giovannini2Chiara Paloni2Davide De Lorenzi3Maria Chiara Marchesi1- 1Universita degli Studi di Perugia Dipartimento di Medicina Veterinaria, Perugia, Italy
- 2Anicura Tyrus Veterinary Clinic, Terni, Italy
- 3San Marco Veterinary Clinic and Laboratory, Veggiano, Italy
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Electrochemotherapy is a local anticancer treatment used for selected cutaneous tumors, but its application in veterinary medicine for nasal neoplasms is only rarely reported. Two dogs with endonasal tumors, ineligible for radiotherapy, underwent endoscopic-guided electrochemotherapy (ECT). Each cycle included three sessions spaced three weeks apart. Under general anesthesia and endoscopic guidance, bleomycin (20,000 IU/m2) was ad-ministered intravenously, followed by bipolar electroporation via a new single needle electrode. Palliative metronomic chemotherapy (piroxicam, thalidomide, and cyclophosphamide) was also administered as an adjuvant to the local treatment. Both dogs showed reduced tumor size and resolution of clinical signs after the third ECT session. Only mild intraoperative bleeding was observed. Follow-up CT and endoscopy confirmed significant volumetric tumor reduction and improved nasal airflow. Endoscopic-guided ECT combined with metronomic chemotherapy appears to be a promising palliative approach for canine endonasal tumors, providing tumor cytoreduction and improvement of clinical signs. Further studies with larger sample sizes and longer follow-up periods are needed to confirm the safety and efficacy of this approach, either alone or in combination with other surgical or medical treatments.
Keywords: Dog4, electrochemotherapy2, endoscopy3, nasal tumor1, oncology5
Received: 28 Nov 2025; Accepted: 26 Jan 2026.
Copyright: © 2026 Maggi, Dentini, Giovannini, Paloni, De Lorenzi and Marchesi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Giulia Maggi
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