CASE REPORT article
Front. Vet. Sci.
Sec. Veterinary Pharmacology and Toxicology
Case Report: Clinical Manifestations Reported in a Canine After Ingesting Ruxolitinib Phosphate (Opzelura®)
Provisionally accepted
- 1SafetyCall International, Bloomington, MN, United States
- 2Pet Poison Helpline, Bloomington, United States
- 3BluePearl Pet Hospital, Phoenix, AZ, United States
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This case report describes a canine patient that developed cardiovascular and ocular abnormalities following ingestion of ruxolitinib phosphate 1.5% topical cream. The objective of this report is to characterize the exposure history, clinical presentation, diagnostic findings, therapeutic interventions, and to evaluate ruxolitinib phosphate within the context of its pharmacologic class, emphasizing similarities with related veterinary medications. Building on a recently published retrospective study of oclacitinib maleate overdoses, this case highlights shared clinical manifestations of ruxolitinib phosphate overdose and contributes to a broader understanding of JAK inhibitor toxicosis in veterinary medicine.
Keywords: Apoquel®, JAK inhibitors, oclacitinib maleate, Opzelura®, Ruxolitinib phosphate
Received: 30 Nov 2025; Accepted: 20 Jan 2026.
Copyright: © 2026 Swanson, Schmid, Butt and Hovda. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lynn R. Hovda
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