BRIEF RESEARCH REPORT article
Front. Vet. Sci.
Sec. Veterinary Pharmacology and Toxicology
This article is part of the Research TopicNatural Compounds in Veterinary Therapeutics - volume IIView all articles
The preventive effect of chlorogenic acid on cisplatin-induced acute kidney injury induced in mice1
Provisionally accepted
- 1Heilongjiang Bayi Agricultural University, Daqing, China
- 2Jilin Agricultural Science and Technology College, Jilin, China
- 3Jilin Agricultural Science and Technology University, Jilin, China
- 4Nanjing Forestry University, Nanjing, China
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Abstract :Acute kidney injury (AKI) is a prevalent clinical syndrome. Chlorogenic acid (CGA) is a natural polyphenol and has antioxidant and anti-inflammatory properties. Sixty male Kunming mice were randomly assigned to six groups: Control (CON), Cisplatin (CIS), CGA, CIS + CGA, CIS + Furosemide (FUR), and FUR group. Kidney injury markers, inflammatory indicators, antioxidant enzyme activities, oxidative product, antioxidant proteins, kidney morphology were evaluated by ELISA, Histology, and Western blot. The results showed that preventive CGA supplementation significantly reduced the contents of Creatinine (Cr), BUN, KIM-1, and MDA, restored the enzymatic activities of SOD, GSH-Px, CAT, and T-AOC vitality. The expression of Nrf2 and GCLC proteins were increased, whereas the expression of Keap1 protein was decreased. IL-1β, IL-2 and IL-6 levels were reduced, while IL-10 levels were elevated. These findings indicated that preventive CGA supplementation effectively mitigates CIS-induced AKI by enhancing antioxidant capacity, attenuating inflammatory responses, and ameliorating kidney structural damage.
Keywords: Acute Kidney Injury, antioxidant capacity, Chlorogenic Acid, Cisplatin, Mice
Received: 09 Dec 2025; Accepted: 26 Jan 2026.
Copyright: © 2026 Zheng, Duan, Zhong, Zhu, Niu, Huang and Yin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Baishuang Yin
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