ORIGINAL RESEARCH article
Front. Vet. Sci.
Sec. Veterinary Infectious Diseases
Genetic Variability and Phylogenetic Analysis of the VP2 Gene of Feline Parvovirus in Harbin
Provisionally accepted
- 1Northeast Agricultural University, Harbin, China
- 2Harbin Vaccine Science Biotechnology Co., Ltd, Harbin, China
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In 2023, a total of 450 fecal samples were collected from healthy cats and those suspected of being infected with Parvovirus in Harbin. The FPV VP2 gene was detected using polymerase chain reaction (PCR), followed by VP2 sequence analysis, phylogenetic analysis, recombination analysis, and selective pressure analysis. The VP2 sequence analysis showed that the nucleotide similarity of the full-length VP2 gene ranged from 98.7% to 100%, with 19 amino acid mutations observed compared to the 2008 Felocell vaccine strain (GenBank:EU49868.1). Phylogenetic analysis demonstrated that all 42 FPV strains clustered with recent domestic isolates, suggesting that the FPV lineages circulating in China have remained relatively stable in recent years. Recombination analysis identified HRB2312 and HRB2324 as recombinant strains of FPV and CPV-2c. Selective pressure analysis did not detect any positively selected sites, indicating that the evolution of FPV is influenced by both random genetic drift and gene recombination. This study provides insights into the genetic diversity of FPV strains circulating in Harbin, highlighting the occurrence of point mutations and genetic recombination. Further investigation is warranted to determine whether the circulating recombinant strains are antigenically compatible with traditional vaccine strains.
Keywords: Feline parvovirus, Genetic Variation, Harbin, phylogenetic analysis, VP2 gene
Received: 08 Jan 2026; Accepted: 04 Feb 2026.
Copyright: © 2026 Luan, Weng, Guo, Yang, Wu, Ding and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Guojie Ding
Yijing Li
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