Neuropeptides and their cognate receptors play a crucial role in modulating social behavior across a wide range of species. Despite their significance, understanding the precise mechanisms by which neuropeptides influence behavior remains challenging due to their widespread expression in various brain regions. This complexity is compounded by the fact that neuropeptides can affect brain function, behavior, and physiology in diverse ways, contingent upon the specific neural circuits in which they are active. Recent advancements in the study of specific neuropeptide circuits have significantly enhanced our comprehension of the multifaceted roles these molecules play in social behavior. However, there remains a gap in fully elucidating the mechanisms at play, particularly in how these circuits contribute to both normal social interactions and the social deficits observed in psychiatric disorders. Addressing these gaps is essential for advancing both basic neuroscience and the development of therapeutic interventions.
This research topic aims to explore the mechanisms through which neuropeptides act on the neural substrates of social behavior. By focusing on specific neuropeptide circuits, the research seeks to provide a comprehensive understanding that can inform both basic research and translational applications. The objective is to broaden the scope beyond the traditionally studied neuropeptides, such as oxytocin and vasopressin, to include a wider array of neuropeptides and their associated circuits. This approach will help elucidate the operating principles of neuropeptide action in social behavior and offer insights into the neural underpinnings of social deficits in psychiatric conditions.
To gather further insights into the diverse roles of neuropeptide circuits in social behavior, we welcome articles addressing, but not limited to, the following themes:
- Identification and characterization of novel neuropeptide circuits involved in social behavior.
- Comparative studies of neuropeptide function across different species.
- Mechanistic insights into how specific neuropeptides influence neural circuits and social behavior.
- The role of neuropeptides in social deficits associated with psychiatric disorders.
- Innovative methodologies for studying neuropeptide circuits and their impact on behavior.
Keywords: Neuropeptides, social circuits, neuropeptide systems
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
