About this Research Topic
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression, mostly through binding to the 3′ untranslated region (3′ UTR) of targeted messenger RNA (mRNA) molecules and, mediating translational repression, usually combined with or followed by mRNA degradation. In recent decades, research on miRNAs has deepened our understanding of their mechanisms of action and their biological functions. In particular, miRNAs can modulate the expression of genes encoding hormones, receptors, as well as the enzymes involved in the maturation of hormones. In addition, miRNA expression can be regulated by hormones. Altogether these findings highlight the critical role of miRNAs in the field of neuroendocrinology and endocrinology.
The field of neuroendocrinology has grown significantly with the clarification of the molecular mechanisms responsible for the synthesis and action of hormones. Over the last few decades, miRNAs became an important topic in molecular and cellular biology as "key modulators" of physiological and pathophysiological processes. They can orchestrate cell-to-cell communication and mediate intra-cellular processes in numerous ways by controlling gene expression at post-transcriptional, and translational levels. The relevant finding in the field of miRNA research is the novel discovery that miRNAs packaged within cell-secreted extra-cellular vesicles could be critical for the cross-talk between different organs in the context of neuroendocrinology. Altogether, miRNAs appear essential in neuroendocrinology in the context of body regulation in the field of puberty, neuroendocrine axis, circadian rhythms, and feeding behavior.
In this Research Topic, we welcome high-quality original research and current review and mini review articles on the relationship between the neuroendocrine system and miRNAs. Moreover, we will highlight recent research and review the role of miRNAs as biomarkers or key regulators in the mechanisms underlying the development of neuroendocrine diseases (i.e. cancer) and their related complications.
• Genes regulation by miRNAs in the context of neuroendocrinology and endocrine system
• Function of micro-RNAs in the production and release of neuro-hormones
• Function of micro-RNAs in the cell signaling
• Micro-RNAs signature in neuroendocrine diseases
• Micro-RNAs and extra-cellular vesicles
• Impact of hormones on micro-RNAs expression
Keywords: Micro-RNA, neuroendocrinology, endocrine system, hormone, gene regulatory network
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