Epigenetic regulation is a burgeoning field of research that explores how modifications such as DNA methylation and histone protein post-translational modifications influence gene expression without altering the DNA sequence. These modifications are crucial in determining the distinct gene expression profiles in specific cells. Disruptions in these epigenetic processes, often due to environmental exposures, can lead to gene function dysregulation, contributing to a wide range of phenotypic outcomes. This is particularly relevant in the context of congenital anomalies of the kidney and urinary tract (CAKUT) and other kidney diseases, where the interplay between genetic and environmental factors is significant. Recent studies have highlighted the potential of understanding the epigenetic basis of kidney development and disease to uncover new pathological mechanisms and therapeutic avenues. However, despite these advances, the precise role of epigenetic mechanisms in kidney development, particularly nephron endowment, remains largely unexplored. Chronic kidney disease (CKD) is a global public health issue, often linked to early-life environmental exposures, underscoring the need for further investigation into epigenetic mechanisms for effective prevention and treatment strategies. While epigenetics has gained prominence in cancer research, its application in kidney disease, including kidney malignancies, is still emerging, with epigenetic therapies showing promise in cancer prevention and treatment.
This research topic aims to delve into the epigenetic regulation of kidney development and disease, seeking to unravel the complex gene-environment interactions that influence nephron endowment and contribute to kidney pathologies. The primary objectives include understanding how epigenetic mechanisms impact kidney development, particularly in the context of congenital anomalies and chronic kidney disease. The research will also explore the potential of epigenetic therapies in treating kidney diseases, including malignancies. By addressing these questions, the research aims to provide new insights into the prevention and treatment of kidney diseases, ultimately improving patient outcomes.
To gather further insights into the epigenetic regulation of kidney development and disease, we welcome articles addressing, but not limited to, the following themes: - Epigenetic regulation of kidney development - Epigenetic mechanisms of chronic kidney disease - Epigenetic mechanisms of acute kidney injury - Epigenetic regulation of kidney tumorigenesis
Descriptive studies (e.g. gene expression profiles, or transcript, protein, or metabolite levels under particular conditions or in a particular cell type) and studies consisting solely of bioinformatic investigation of publicly available genomic / transcriptomic data do not fall within the scope of the journal unless they are expanded and provide significant biological or mechanistic insight into the process being studied.
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Article types
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
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