Respiratory syncytial virus (RSV) is one of the major infectious agents in pediatrics with acute lower respiratory tract infections, accounting for 60–80% of bronchiolitis presentations. As an enveloped negative-sense single-stranded RNA virus of the family Pneumoviridae and the order Mononegavirales, RSV has 10 genes coding for 11 proteins, including the G glycoprotein and the fusion glycoprotein(F) that control viral attachment and the initial stages of infection and other structural or other structural proteins.
Over the years, there have been increasing reports investigating the virology and pathogenicity of RSV, and perspectives on the diagnosis, epidemiology and treatment of RSV infection have also been presented. However, despite years of research and medical trials, the specific molecular viral pathogenesis still needs to be illustrated. No approved vaccine or small-molecule drug is available for RSV-bronchiolitis, and the mainstay of bronchiolitis treatment remains supportive only.
Therefore, further studies are urgently needed to explore pathogenesis and epidemiology in infant RSV-bronchiolitis, which is of great significance for the therapeutic development of severe RSV-bronchiolitis.
In this research topic, we focus on the virus-host interaction in RSV infection and the epidemiology of RSV infection in children, aiming at developing therapeutic strategies for severe RSV-bronchiolitis, which are a vital threat to the public health of infants.
The scope of this Research Topic includes, but is not limited to, the following research areas:
1. Molecular epidemiology of RSV in children
2. Mechanisms of RSV infection (adhesion, invasion, and survival within the host)
3. Molecular viral pathogenesis of RSV-bronchiolitis
4. New therapeutic targets
Keywords:
Pathogenesis, RSV, Epidemiology, Therapeutic strategies, Virus-host interaction
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Respiratory syncytial virus (RSV) is one of the major infectious agents in pediatrics with acute lower respiratory tract infections, accounting for 60–80% of bronchiolitis presentations. As an enveloped negative-sense single-stranded RNA virus of the family Pneumoviridae and the order Mononegavirales, RSV has 10 genes coding for 11 proteins, including the G glycoprotein and the fusion glycoprotein(F) that control viral attachment and the initial stages of infection and other structural or other structural proteins.
Over the years, there have been increasing reports investigating the virology and pathogenicity of RSV, and perspectives on the diagnosis, epidemiology and treatment of RSV infection have also been presented. However, despite years of research and medical trials, the specific molecular viral pathogenesis still needs to be illustrated. No approved vaccine or small-molecule drug is available for RSV-bronchiolitis, and the mainstay of bronchiolitis treatment remains supportive only.
Therefore, further studies are urgently needed to explore pathogenesis and epidemiology in infant RSV-bronchiolitis, which is of great significance for the therapeutic development of severe RSV-bronchiolitis.
In this research topic, we focus on the virus-host interaction in RSV infection and the epidemiology of RSV infection in children, aiming at developing therapeutic strategies for severe RSV-bronchiolitis, which are a vital threat to the public health of infants.
The scope of this Research Topic includes, but is not limited to, the following research areas:
1. Molecular epidemiology of RSV in children
2. Mechanisms of RSV infection (adhesion, invasion, and survival within the host)
3. Molecular viral pathogenesis of RSV-bronchiolitis
4. New therapeutic targets
Keywords:
Pathogenesis, RSV, Epidemiology, Therapeutic strategies, Virus-host interaction
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.