About this Research Topic
Increased evidence supports the important role of immune system in aging and age-related diseases. As a paradigmatic example, aging has been associated with delays in bone healing in humans. The risk of OA increases with age, while OA increases age-related morbidity and mortality in older adults. Immune cells actively infiltrate OA synovial tissues and produce pro-inflammatory cytokines and extracellular vesicles into the joint tissue and synovial fluid to enhance inflammatory responses and tissue damage. Then, a large human cohort study (n=1507) recently reported observations in older adults, yielded from causal analyses, that lymphocytes were potentiators, whereas neutrophils were attenuators of longevity. Therefore, it is highly valuable to promote research on identifying age-related alternations and dysfunctions in the immune system, and the mechanisms by which age-mediated immune dysfunctions influence the development of diseases in older adults.
This research topic welcomes Original Research Articles and Review/Mini-review reporting observations and mechanisms related to immunity in aging and age-related diseases and dysfunctions, including but not limited to the following areas:
Immunity and biological age
Age-related pro-inflammatory status
Mechanisms of dysfunctions in the aged immune systems
Autoimmune response and aging
Infections and immunosenescence
Vaccination and immunosenescence
Interactions between immune system and tissue during aging
Role of the sex and gender in immunosenescence
The role of sex/gender in the pro-inflammatory status in ageing
Immunity-related mechanisms of anti-aging therapies
Keywords: Immunity, Immune aging, Immunosenescence, Inflammaging, Diseases, Dysfunctions, Sex, Gender
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.