Conventional approaches to immunotherapy typically require systemic immune stimulation, which is often associated with autoimmune disorders. Nanotechnology strategies have been explored as an alternative strategy to delivering immune stimulating molecules. Several studies have demonstrated the potential of nanoparticle-based delivery systems to overcome biological barriers and modulate immune responses. Nanoparticle-based therapeutics are being explored to directly modulate immune responses with key advantages, including modularity, high efficacy, and rapid manufacturing. Currently, nanoparticles have been widely used to develop new vaccines and therapies to prevent or treat diseases. Thus, nanomedicine can be applied in several approaches to combat infections caused by bacteria, virus, protozoan, to modulate tumor microenvironment as well as autoimmune disease.
Inflammatory diseases such as autoimmune diseases, cancer, and infectious diseases continue to pose significant challenges in the medical field, causing considerable morbidity and mortality globally. These conditions have complex and diverse pathologies that make their treatment difficult. Traditional approaches such as chemotherapy, surgery, and radiation therapy often have limitations, including significant side effects. In recent years, immunotherapy has emerged as a promising approach for the treatment of inflammatory diseases. Immunotherapy involves using the body's immune system to fight the disease by stimulating, modulating, or restoring its natural defense mechanisms. However, the effectiveness of immunotherapy often depends on the ability to deliver therapeutic agents to the target site while minimizing off-target effects and reducing toxicity. To address these challenges, researchers have been exploring the potential of nanoparticle-based delivery systems for immunotherapy. Our goal throughout this research topic is to provide perspective and insights into novel nanoparticle-based delivery systems that can improve the efficacy, modulation, and safety of immunotherapies to advance their clinical translation and improve patient outcomes.
This research topic aims to cover various aspects of the use of nanotechnology in modulating the host immune response for the treatment of autoimmune diseases, cancer, and infectious diseases. The scope of this topic includes Original Research, Brief Research Report, Systematic Review that demonstrate the use of nanoparticle-based delivery systems can deliver nucleic acids, adjuvants, antigens, small molecules and can modulate the immune response, reduce inflammation and promote tissue repair as well as cell engineering and the development of vaccines. Overall, this research topic aims to provide insights into the use of nanotechnology in modulating the host immune response for the treatment of autoimmune diseases, cancer, and infectious diseases. It will cover various aspects of nanotechnology-based delivery systems, including their design, development, characterization, and preclinical and clinical evaluation.
The Topic Editors declare no competing interests with regard to the Research Topic subject.
Keywords: nanotechnology, nanoparticles, drug delivery, gene delivery, immunomodulation, immunotherapy, autoimmune diseases, cancer, infectious diseases
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