Modeling the Immune System: from PK/PD to Systems Immunology

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ORIGINAL RESEARCH

Published on 17 Feb 2026

Identification of predictive biomarkers and dose optimization for camrelizumab combined with apatinib in the treatment of advanced hepatocellular carcinoma: a quantitative systems pharmacology approach

Weikun Huang
Guihui Tu
Dandan Li
Chenyu Wang
Jianxing Zhou
Zheng Jiao
Lin Yang

doi 10.3389/fimmu.2026.1617227

178 views

EDITORIAL

Published on 17 Feb 2026

Editorial: Modeling the immune system: from PK/PD to systems immunology

Lucía Alfonso-González
Francisco J. Fernández
M. Cristina Vega

doi 10.3389/fimmu.2026.1800899

240 views

MINI REVIEW

Published on 05 Sep 2025

Systems immunology: When systems biology meets immunology

Lucía Alfonso-González
Francisco J. Fernández
M. Cristina Vega

doi 10.3389/fimmu.2025.1630488

4,233 views
5 citations

PERSPECTIVE

Published on 29 May 2025

Multi-physiology modeling of the immune system in the era of precision immunotherapy

Sunghyun Hong
Kyemyung Park

doi 10.3389/fimmu.2025.1548768

2,894 views

ORIGINAL RESEARCH

Published on 25 Apr 2025

A computational account of joint SSRI and anti-inflammatory treatment

Melissa Reneaux
Helen Mayberg
Karl Friston
Dimitris A. Pinotsis

doi 10.3389/fimmu.2025.1472732

2,596 views
3 citations

ORIGINAL RESEARCH

Published on 25 Feb 2025

In-depth immunochemical characterization of the serum antibody response using a dual-titration microspot assay

Ágnes Kovács
Zoltán Hérincs
Krisztián Papp
Jakub Zbigniew Kaczmarek
Daniel Nyberg Larsen
Pernille Stage
László Bereczki
Eszter Ujhelyi
Tamás Pfeil
József Prechl

doi 10.3389/fimmu.2025.1494624

1,737 views
3 citations

ORIGINAL RESEARCH

Published on 28 Feb 2024

Investigating the ability of deep learning-based structure prediction to extrapolate and/or enrich the set of antibody CDR canonical forms

Alexander Greenshields-Watson
Brennan Abanades
Charlotte M. Deane

doi 10.3389/fimmu.2024.1352703

4,369 views
8 citations

ORIGINAL RESEARCH

Published on 13 Feb 2024

Drug-target identification in COVID-19 disease mechanisms using computational systems biology approaches

Anna Niarakis
Marek Ostaszewski
Alexander Mazein
Inna Kuperstein
Martina Kutmon
Marc E. Gillespie
Akira Funahashi
Marcio Luis Acencio
Ahmed Hemedan
68 more
the COVID-19 Disease Map Community

doi 10.3389/fimmu.2023.1282859

11,121 views
17 citations

ORIGINAL RESEARCH

Published on 22 Jan 2024

Highly heterogenous humoral immune response in Lyme disease patients revealed by broad machine learning-assisted antibody binding profiling with random peptide arrays

L. Kelbauskas
J. B. Legutki
N. W. Woodbury

doi 10.3389/fimmu.2024.1335446

3,042 views
4 citations

ORIGINAL RESEARCH

Published on 26 Oct 2022

A network view of human immune system and virus-human interaction

Kang Tang
Jing Tang
Jinfeng Zeng
Wei Shen
Min Zou
Chi Zhang
Qianru Sun
Xiaoyan Ye
Chunwei Li
3 more
Xiangjun Du

doi 10.3389/fimmu.2022.997851

3,801 views
4 citations

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Systems Immunology

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