Bone Marrow Aging and its Impact on Immunosenescence in Neurological Diseases

The aging of the immune system has drawn a lot of attention in neurological diseases including multiple sclerosis, stroke, and neurodegenerative diseases. This phenomenon, referred to as immunosenescence, is of particular interest due to its potential role in initiating chronic inflammation, impairing the clearance of abnormally folded proteins, and impeding neural repair processes. These consequences of immunosenescence may heighten the susceptibility of neurological diseases and impact their overall progression and outcomes.

One critical aspect contributing to immunosenescence is bone marrow aging, which exerts substantial influence over the production and functionality of immune cells, subsequently exerting adverse effects on the central nervous system. However, the mechanisms underlying how bone marrow aging interplays with immunosenescence and attributes to the onset and progression of neurological diseases remain largely unclear.

The primary objective is to elucidate the underlying mechanisms through which bone marrow aging influences the occurrence and progression of immunosenescence, and subsequently, how immunosenescence contributes to the pathogenesis of neurological diseases. By achieving this goal, we aim to provide a deeper understanding of the complex interplay between these processes, and develop targeted interventions and therapeutic strategies to mitigate the impact of immunosenescence on neurological health in aging populations. Recent advances in genomics, proteomics, and single-cell sequencing can help explore cellular and molecular changes associated with these processes. Advanced animal models can be utilized to mimic bone marrow aging and immunosenescence.

Recent advances in neuroimaging, biomarker identification, and data analysis can provide valuable insights into these processes in patients. Immunomodulatory therapies may be utilized as interventions targeting immunosenescence and its impact on neurological diseases.

This Research Topic accepts Original Research, Systematic Review, Methods, Review and Mini-Review, Policy and Practice Reviews, Hypothesis & Theory, Clinical Trial, Classification, Technology and Code, Study Protocol, Perspective, Case Report, Conceptual Analysis, Curriculum, Instruction, and Pedagogy, Brief Research Report, Data Report, General Commentary, Opinion. We welcome manuscripts focusing on, but not limited to, the following sub-topics:

• Mechanisms underlying the aging of bone marrow and its impact on immune cell production
• The hallmarks of immunosenescence, including changes in immune cell function, immune cell subsets, and immune signalling pathways, particularly in the context of aging
• The association between immunosenescence and neuroinflammaiton
• The impact of immunosenescence in the clearance of pathological proteins and neural repair
• The role of immunosenescence in the development of neurological diseases, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and others
• Identify biomarkers of immunosenescence and their potential utility in predicting neurological disease risks
• Explore potential therapeutic interventions aimed at modulating immunosenescence.



The Topic Editors declare no competing interests with regard to the Research Topic subject.

Keywords: Bone marrow aging, immunosensescence, neurological diseases, neuroinflammation, neural repair

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