Role and Mechanism of Regulated Cell Death in Musculoskeletal Development, Homeostasis, and Diseases

Regulated cell death (RCD) is a pivotal process in human physiology, particularly within the musculoskeletal system, where it ensures proper development and homeostasis by eliminating superfluous or dysfunctional cells. However, disruptions in RCD balance, often due to aging or environmental changes, can lead to increased cell death and impaired cell function, contributing to musculoskeletal disorders such as intervertebral disc degeneration, osteoporosis, and osteoarthritis. Over the past two decades, various modes of RCD, including PANoptosis, oxeiptosis, alkaliptosis, necroptosis, ferroptosis, and cuproptosis, have been identified, each with distinct molecular mechanisms. Despite these advancements, there remains a significant gap in understanding the precise roles and mechanisms of RCD in musculoskeletal health and disease. Addressing this gap is crucial for developing effective preventative and therapeutic strategies.

This research topic aims to unite experts in musculoskeletal biology, cell death regulation, and the pathogenesis of musculoskeletal diseases to delve into the role and mechanisms of regulated cell death in musculoskeletal development, homeostasis, and diseases. By fostering a comprehensive understanding of these intricate processes, the research seeks to enhance our knowledge of musculoskeletal health and disease pathogenesis. Ultimately, the goal is to identify novel therapeutic targets and strategies for treating musculoskeletal diseases, thereby improving patient outcomes and quality of life.

To gather further insights into the role and mechanisms of regulated cell death in musculoskeletal development, homeostasis, and diseases, we welcome articles addressing, but not limited to, the following themes:
- Regulated cell death in the development of bone, cartilage, and intervertebral discs.
- The role of regulated cell death in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
- Mechanisms of regulated cell death in intervertebral disc degeneration and spinal cord injury.
- The impact of regulated cell death on bone tumors, scoliosis, and osteoporosis.
- Exploration of novel forms of regulated cell death in musculoskeletal health and diseases.

Keywords: Regulated Cell Death, Bone, Cartilage, Intervertebral disc, Pyroptosis, Necroptosis, Ferroptosis, Alkaliptosis, Oxeiptosis, PANoptosis, Cuproptosis

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.