Decoding Epigenetics in Vascular Health: From Basic Science to Therapeutics

At the core of vascular pathologies, a critical transformation occurs as cells undergo epigenetic-induced phenotypic transitions, adopting roles that promote disease. These changes are mediated by a network of epigenetic players, including various modifiers and non-coding RNAs, that regulate gene expressions with high specificity. Traditionally seen as broad regulators, recent insights reveal their pivotal, context-dependent roles in vascular health. Nonetheless, despite their proven potential as drug targets, the translation to clinical settings is impeded by our limited understanding of the intricate epigenetic and signaling pathways involved.

This Research Topic aims to delve deep into the nuances of vascular epigenetic mechanisms to improve the prevention, diagnosis, and treatment of vascular diseases, making significant strides from fundamental research to clinical applications.

This research endeavors to cover a wide array of vascular health issues related to epigenetic regulation. We define our focus on:
• Epigenetic writers, readers, and erasers
• Impact of non-coding RNAs like miRNAs, lncRNA, and circular RNAs
• Metabolic influences on chromatin structures

We cordially invite contributions in the form of:
• Experimental research papers
• Comprehensive reviews
• Case studies
• Methodological advancements

Keywords: Epigenetic writers, readers, and erasers, modifiers of histone, DNA, and RNA, non-coding RNA, vascular disease, mechanism, pharmacological or genetic intervention, technologies to aid translation, Epigenetic therapy vascular disease, Non-coding RNA cardiovascular, Vascular cell gene regulation, Histone modification vascular therapy, DNA methylation cardiovascular disease, Epigenetic biomarkers vascular health, Translational medicine epigenetics, Epigenetic drug targets vascular, Chromatin remodeling cardiovascular, Therapeutic epigenetics in vascular diseases, RNA methylation cardiovascular disease

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.