Optimizing GLP-1 Receptor Agonist Use: Mechanisms, Clinical Applications, and Safety Profiles

GLP-1 receptor agonists have gained popularity due to their dual benefits in managing Type-II diabetes and promoting significant weight loss. The unique mechanism of action, which includes glucose control, appetite suppression, and potential cardiovascular benefits, has positioned these agents as versatile and attractive options for clinicians seeking comprehensive solutions in metabolic health management and, more recently, for patients seeking pharmacological weight loss solutions. Derived from the naturally occurring glucagon-like peptide-1, GLP-1 receptor agonists play a central role in regulating glucose homeostasis and satiety. Understanding the molecular mechanisms, pharmacokinetics, and clinical outcomes associated with GLP-1 receptor agonists is crucial for optimizing their use in various medical contexts, as well as assessing potential complications.

The aim of this Research Topic is to provide a rigorous and comprehensive examination of the developments and challenges surrounding GLP-1 receptor agonists, focusing on their safety, efficacy, and broader implications in clinical practice. By synthesizing the latest research findings, exploring real-world applications, and critically analyzing the multifaceted aspects of GLP-1 receptor agonist therapeutics, we seek to equip healthcare professionals, researchers, and policymakers with a nuanced understanding. Ultimately, this knowledge will facilitate evidence-based decision-making, further advancing the field of metabolic health and ensuring the responsible and effective integration of GLP-1 receptor agonists into diverse medical contexts. We aim to highlight the latest advances in research into GLP-1 receptor agonists and will consider manuscripts including but not limited to the following subtopics:

Mechanisms of Action in GLP-1 Receptor Agonists

Clinical Applications: GLP-1 Agonists in Type-II Diabetes and Weight Loss

Molecular Insights and Pharmacokinetics of GLP-1 Receptor Agonists

Safety Profiles and Complications of GLP-1 Agonists

Efficacy Assessments and Optimization Strategies for GLP-1 Agonists

Challenges in Clinical Implementation of GLP-1 Receptor Agonists

Interdisciplinary Perspectives on GLP-1 Agonists in Metabolic Health

Advances in Research on GLP-1 Receptor Agonists

Evidence-Based Decision-Making for GLP-1 Agonists in Clinical Settings

Responsible Integration of GLP-1 Receptor Agonists into Diverse Medical Contexts

We welcome a variety of article types, including under the following categories: Original Research, Review, Mini Review, Brief Research Report, and Perspective.

Keywords: GLP-1 Receptor Agonists, Glucagon-Like Peptide-1, Type-II Diabetes, Weight Loss, Metabolic Health

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.