Dementia and depression are distinct yet frequently concurrent conditions that profoundly affect an individual's cognitive and emotional well-being. Dementia involves symptoms that impair memory, thinking, and social skills, hindering daily functioning. Conversely, depression is characterized by persistent feelings of sadness, hopelessness, and disinterest in activities. Their coexistence presents unique challenges in diagnosis, treatment, and management.
Advanced diffusion MRI techniques provide valuable insights into the neural complexities of dementia and depression. These methods allow researchers to examine the microstructural integrity of white matter tracts, detect subtle changes in neural connectivity, and understand the interaction between structural alterations in dementia and neural aspects of depression. This topic aims to investigate the neural intricacies of comorbid dementia and depression using advanced MRI techniques. By uncovering the structural dynamics and interplay between these conditions, the goal is to enhance diagnostics and interventions for individuals facing this complex intersection of mental health disorders.
The objective of this research topic is to delve into the neural complexities experienced by individuals coping with both dementia and depression, employing advanced diffusion MRI techniques such as free-water DTI (both single- and multi-shell), Kurtosis dMRI, generalized Q-sampling imaging (GQI), structural connectivity, and others. Additionally, standard DTI techniques will be considered. Through this investigation, we aim to uncover subtle alterations in neural connectivity linked to these conditions and elucidate the interaction between structural changes observed in dementia and the neural correlates of depression. Ultimately, the goal is to enhance diagnostic precision and formulate targeted interventions for individuals navigating the complex overlap of these prevalent mental health disorders.
This research topic delves into the intricate relationship between dementia and depression, two prevalent mental health conditions that profoundly affect cognitive and emotional well-being. Dementia encompasses cognitive decline, including memory loss and behavioral changes, while depression is characterized by persistent sadness and disinterest. Their frequent co-occurrence complicates diagnosis and management. While various MRI techniques have individually explored dementia and depression, there is limited research on individuals with both conditions. The primary aim of this topic is to investigate alterations in white matter structural integrity associated with dementia and depression. Studies utilizing Diffusion Tensor Imaging (DTI) and advanced diffusion MRI methods capable of assessing white matter integrity are of particular interest.
Authors are invited to contribute original research articles, reviews, and perspectives that deepen our understanding in this field. By utilizing innovative diffusion MRI methodologies, they can provide insights into potential diagnostic and therapeutic avenues.
Example topics include:
- Examining White Matter Integrity in Late-Life Depression and Dementia
- Exploring Early Cognitive Decline Detection in Depression Through Diffusion MRI
- Examining dMRI’s Role in Monitoring Treatment Response for Depression and Dementia
- Advanced dMRI Connectomics Studies Investigating Structural Brain Networks in Individuals with Depression and Dementia
- Exploring Neuroinflammation and White Matter Changes in Individuals Affected by Depression and Dementia
- Longitudinal Investigation of White Matter Changes in Individuals with Depression and Dementia
- Exploring the Impact of Genetics and Environment on White Matter Integrity
- Investigating Cerebellar Involvement in Individuals with Dementia and Depression Using dMRI
Eligible Methodologies include:
- Studies that employ a combination of Diffusion Tensor Imaging (DTI) and advanced diffusion MRI (dMRI) techniques, including Generalized Q-Sampling Imaging (GQI), Quantitative Scalar Diffusion-Weighted Imaging (QSDR), Diffusion Kurtosis Imaging (DKI), and Diffusion Spectrum Imaging (DSI), to examine alterations in white matter integrity among individuals affected by both dementia and depression.
- Studies that employ various analysis methodologies for dMRI, such as free-water DTI with both single- and multi-shell acquisitions, voxel-based and ROI analyses, tractography, and fixel-based analysis (FBA).
- Cross-sectional, longitudinal, and review studies.
Keywords:
Diffusion MRI (dMRI), Dementia, Diffusion tensor imaging (DTI), Depression, Magnetic Resonance Imaging (MRI), Alzheimer's
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Dementia and depression are distinct yet frequently concurrent conditions that profoundly affect an individual's cognitive and emotional well-being. Dementia involves symptoms that impair memory, thinking, and social skills, hindering daily functioning. Conversely, depression is characterized by persistent feelings of sadness, hopelessness, and disinterest in activities. Their coexistence presents unique challenges in diagnosis, treatment, and management.
Advanced diffusion MRI techniques provide valuable insights into the neural complexities of dementia and depression. These methods allow researchers to examine the microstructural integrity of white matter tracts, detect subtle changes in neural connectivity, and understand the interaction between structural alterations in dementia and neural aspects of depression. This topic aims to investigate the neural intricacies of comorbid dementia and depression using advanced MRI techniques. By uncovering the structural dynamics and interplay between these conditions, the goal is to enhance diagnostics and interventions for individuals facing this complex intersection of mental health disorders.
The objective of this research topic is to delve into the neural complexities experienced by individuals coping with both dementia and depression, employing advanced diffusion MRI techniques such as free-water DTI (both single- and multi-shell), Kurtosis dMRI, generalized Q-sampling imaging (GQI), structural connectivity, and others. Additionally, standard DTI techniques will be considered. Through this investigation, we aim to uncover subtle alterations in neural connectivity linked to these conditions and elucidate the interaction between structural changes observed in dementia and the neural correlates of depression. Ultimately, the goal is to enhance diagnostic precision and formulate targeted interventions for individuals navigating the complex overlap of these prevalent mental health disorders.
This research topic delves into the intricate relationship between dementia and depression, two prevalent mental health conditions that profoundly affect cognitive and emotional well-being. Dementia encompasses cognitive decline, including memory loss and behavioral changes, while depression is characterized by persistent sadness and disinterest. Their frequent co-occurrence complicates diagnosis and management. While various MRI techniques have individually explored dementia and depression, there is limited research on individuals with both conditions. The primary aim of this topic is to investigate alterations in white matter structural integrity associated with dementia and depression. Studies utilizing Diffusion Tensor Imaging (DTI) and advanced diffusion MRI methods capable of assessing white matter integrity are of particular interest.
Authors are invited to contribute original research articles, reviews, and perspectives that deepen our understanding in this field. By utilizing innovative diffusion MRI methodologies, they can provide insights into potential diagnostic and therapeutic avenues.
Example topics include:
- Examining White Matter Integrity in Late-Life Depression and Dementia
- Exploring Early Cognitive Decline Detection in Depression Through Diffusion MRI
- Examining dMRI’s Role in Monitoring Treatment Response for Depression and Dementia
- Advanced dMRI Connectomics Studies Investigating Structural Brain Networks in Individuals with Depression and Dementia
- Exploring Neuroinflammation and White Matter Changes in Individuals Affected by Depression and Dementia
- Longitudinal Investigation of White Matter Changes in Individuals with Depression and Dementia
- Exploring the Impact of Genetics and Environment on White Matter Integrity
- Investigating Cerebellar Involvement in Individuals with Dementia and Depression Using dMRI
Eligible Methodologies include:
- Studies that employ a combination of Diffusion Tensor Imaging (DTI) and advanced diffusion MRI (dMRI) techniques, including Generalized Q-Sampling Imaging (GQI), Quantitative Scalar Diffusion-Weighted Imaging (QSDR), Diffusion Kurtosis Imaging (DKI), and Diffusion Spectrum Imaging (DSI), to examine alterations in white matter integrity among individuals affected by both dementia and depression.
- Studies that employ various analysis methodologies for dMRI, such as free-water DTI with both single- and multi-shell acquisitions, voxel-based and ROI analyses, tractography, and fixel-based analysis (FBA).
- Cross-sectional, longitudinal, and review studies.
Keywords:
Diffusion MRI (dMRI), Dementia, Diffusion tensor imaging (DTI), Depression, Magnetic Resonance Imaging (MRI), Alzheimer's
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.