The interplay between diets, microbiota, bacterial metabolites, and the host is a burgeoning field of research that holds significant implications for intestinal health and disease. It is increasingly recognized that the gut microbiota and their metabolites, such as short-chain fatty acids and bile acids, play a crucial role in modulating the host's metabolic status, educating the intestinal immune system, and providing protection against pathogens and injury. Environmental factors, particularly diets and dietary components, are pivotal in shaping the microbiota, thereby influencing immune and epithelial responses and ultimately determining an individual's health status. Disruptions in these interactions have been linked to various conditions, including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), colorectal cancer, obesity, Parkinson's disease, autism, and asthma. While Westernized diets high in fat and sugar and low in fiber, along with dietary additives like emulsifiers, have been identified as risk factors, other dietary patterns such as the Mediterranean and Ketogenic diets, as well as probiotics and prebiotics, offer potential therapeutic benefits by positively impacting the microbiota and host.
This Research Topic aims to explore the complex interactions between diet, microbiota, bacterial metabolites, and the host, with the objective of advancing our understanding of their collective impact on intestinal health and disease. The research will focus on elucidating the mechanisms by which food and its components, along with commensal and pathogenic bacteria and their metabolites, regulate immune and epithelial responses in the gut. Additionally, the research seeks to develop and utilize new in vitro and in vivo models and omics technologies to investigate these interactions comprehensively. Ultimately, the goal is to identify novel treatment strategies derived from diets, dietary components, bacterial strains, or metabolites for managing intestinal disorders.
To gather further insights into the intricate relationships between diet, microbiota, and host interactions, we welcome articles addressing, but not limited to, the following themes: - Mechanisms regulated by food, food components, commensal versus pathogenic bacteria, and bacterial metabolites on immune and epithelial responses in the gut, such as T cell response, antigen presentation, barrier function, and cell death. - Development and application of new in vitro and in vivo models and omics technologies to study food-microbiota, food-host, microbiota-host, bacterial metabolite-host, and food-microbiota-host interactions. - Exploration of new treatment strategies derived from innovative diets, dietary components, bacterial strains, or bacterial metabolites for the treatment of intestinal disorders.
Article types and fees
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Case Report
Classification
Clinical Trial
Editorial
FAIR² Data
General Commentary
Hypothesis and Theory
Methods
Mini Review
Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.
Article types
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
