About this Research Topic
Diabetes etiology is diverse, broadly categorized into Type 1 Diabetes (T1D) and Type 2 Diabetes (T2D). T1D involves the autoimmune destruction of β-cells, leading to loss of insulin production, while T2D is characterized by inadequate insulin response due to increased insulin resistance. While T1D remains the most prevalent among children, especially in European populations, T2D is emerging as a significant global public health issue among adolescents, particularly in high-risk ethnic groups and those with obesity. The incidence of both T1D and T2D in youth is increasing following overlapping factors, such as the obesity epidemic. This rise is particularly pronounced in some ethnic groups, influenced by both genetics and environmental factors such as western diet and low physical activity. It is known that genetics play an important role in the pathogenesis of T1D, along with specific environmental factors such as gut microbiota and immune system exposures, although the interaction with obesity has been creating challenges to conventional perceptions of metabolic disease and T1D. Insulin replacement in youth with T1D and obesity results in a vicious cycle of insulin resistance and weight gain culminating in a dual burden and worse outcomes. In this line, we should explore how environmental and biopsychosocial factors may impact youth living with T1D and how it might influence obesity, highlighting therapeutic interventions such as physical activity, nutrition, and pharmacotherapy to manage this dual burden effectively.
The goal of this Research Topic is to shed light on the complex interplay between genetic predisposition and environmental factors, including obesity, in the development, prevention and treatment of type 1 and type 2 diabetes in the pediatric population.
Our objective is to piece together a collection of high-quality, peer-reviewed articles from established experts in the field of diabetology and metabolism that provide insight into both the current state of the field and potential future directions. We are particularly interested in papers that bridge the gap between basic science and clinical applications, demonstrating how experimental knowledge can support medical innovation and advances in clinical practice.
Scope of Contributions:
- Original Research: Cutting-edge studies exploring genetic and environmental interactions affecting metabolic health.
- Reviews and Systematic Reviews: Comprehensive overviews of the current knowledge, including emerging technologies and methodologies.
- Clinical Practice Guidelines and Policy Reviews: Practical applications and guidelines for pediatric endocrinologists.
- Case Reports: Detailed analyses of unique cases that highlight specific challenges or innovations in diagnosis and treatment.
- Perspectives and Commentaries: Expert opinions and debates on controversial or emerging topics.
Suggested Themes of Interest:
- Genetic markers of susceptibility in pediatric metabolic disorders.
- The impact of environmental factors such as diet, lifestyle, and pollution on pediatric diabetes (type 1 and 2) and obesity – from prevention to treatment.
- Innovations in the treatment and management of childhood obesity and its complications.
- The role of childhood obesity pharmacotherapies in preventing the development of type 2 diabetes.
- The role of maternal health in fetal development and pediatric endocrine disorders.
- Advances in understanding and managing other disorders in children affected by diabetes and obesity.
We encourage submissions from researchers and clinicians who are pioneering new insights and techniques in these areas. This collection is intended to be a central resource for pediatric endocrinologists who wish to stay informed of the latest developments and research in this field.
The goal of this Research Topic is to shed light on the complex interplay between genetic predisposition and environmental factors, including obesity, in the development, prevention and treatment of type 1 and type 2 diabetes in the pediatric population.
Our objective is to piece together a collection of high-quality, peer-reviewed articles from established experts in the field of diabetology and metabolism that provide insight into both the current state of the field and potential future directions. We are particularly interested in papers that bridge the gap between basic science and clinical applications, demonstrating how experimental knowledge can support medical innovation and advances in clinical practice.
Scope of Contributions:
- Original Research: Cutting-edge studies exploring genetic and environmental interactions affecting metabolic health.
- Reviews and Systematic Reviews: Comprehensive overviews of the current knowledge, including emerging technologies and methodologies.
- Clinical Practice Guidelines and Policy Reviews: Practical applications and guidelines for pediatric endocrinologists.
- Case Reports: Detailed analyses of unique cases that highlight specific challenges or innovations in diagnosis and treatment.
- Perspectives and Commentaries: Expert opinions and debates on controversial or emerging topics.
Suggested Themes of Interest:
- Genetic markers of susceptibility in pediatric metabolic disorders.
- The impact of environmental factors such as diet, lifestyle, and pollution on pediatric diabetes (type 1 and 2) and obesity – from prevention to treatment.
- Innovations in the treatment and management of childhood obesity and its complications.
- The role of childhood obesity pharmacotherapies in preventing the development of type 2 diabetes.
- The role of maternal health in fetal development and pediatric endocrine disorders.
- Advances in understanding and managing other disorders in children affected by diabetes and obesity.
We encourage submissions from researchers and clinicians who are pioneering new insights and techniques in these areas. This collection is intended to be a central resource for pediatric endocrinologists who wish to stay informed of the latest developments and research in this field.
Keywords: Diabetes, metabolic syndrome, genetic predisposition, environmental factors, development, pediatrics, pediatric diabetes
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
