About this Research Topic
Lung cancer is one of the leading malignancies in terms of incidence and mortality rates, partly due to late diagnosis, therapeutic failure, and drug resistance, which lead to disease progression. Representing a major health burden worldwide, non-small cell lung cancer (NSCLC) is the predominant type of lung cancer, accounting for approximately 85% of all lung cancer cases, and is comprised of adenocarcinoma, squamous-cell carcinoma, and large-cell carcinoma subtypes. Despite advances in targeted therapies and immunotherapies, the prognosis for NSCLC patients remains poor, necessitating ongoing research into novel and effective treatment strategies. This Research Topic focuses on the burgeoning field of non-coding RNAs, specifically circular RNAs (circRNAs) and microRNAs (miRNAs), which have shown potential to revolutionize our understanding and management of NSCLC. Circular RNAs are single-stranded, covalently closed RNAs that may or may not have coding properties and can modulate gene expression through various mechanisms, including microRNA sponging. MicroRNAs are non-coding RNAs that modulate gene expression via mRNA degradation and translational repression, although alternative mechanisms for their action also exist. Through their stability and implication in cancer, circRNAs and miRNAs represent promising biomarkers for early NSCLC detection and potential therapeutic targets.
The key to improving the current diagnostic and therapeutic approaches for NSCLC lies in understanding the role of circular RNAs and microRNAs in carcinogenesis and cancer progression. Despite their potential, there are no validated circular RNA- or microRNA-derived biomarkers for diagnosis, nor are there any circular RNAs and microRNAs that can be used for targeted therapeutics. This underscores the urgency and importance of the research in this field.
Furthermore, the discovery of non-coding RNAs has significantly altered our understanding of the molecular underpinnings of cancer. CircRNAs and miRNAs have been identified as crucial regulators in numerous cellular processes, including proliferation, apoptosis, and metastasis. However, their roles in NSCLC are not fully understood, and the clinical applications of this knowledge are still in the early stages. This Research Topic seeks to bridge these gaps by highlighting the latest research and encouraging interdisciplinary collaborations. We aim to catalyze breakthroughs in NSCLC diagnosis, prognosis, and therapeutic interventions by addressing these gaps.
We invite molecular biology, oncology, and translational medicine researchers to contribute to this Research Topic. Potential submissions include original research, comprehensive review articles, and perspectives, among other types of articles. We particularly welcome studies that provide insights into the molecular mechanisms, potential clinical applications, and therapeutic innovations concerning circRNAs and miRNAs in NSCLC.
The contributions to this Research Topic are expected to advance our understanding of NSCLC at a molecular level, promoting the development of novel diagnostic and therapeutic tools. This collection of articles is anticipated to enhance current treatment paradigms and set a new direction for future research and clinical practices related to NSCLC. By providing a platform for the latest research in circRNAs and miRNAs in NSCLC, this Research Topic will foster significant advancements and inspire ongoing investigations into their potential to change the landscape of cancer therapy.
The objectives of this Research Topic are to:
1. Highlight novel research on the biogenesis and function of circRNAs and miRNAs in NSCLC.
2. Explore the association of circRNAs and miRNAs with tumor progression, metastasis, and resistance to current treatments.
3. Investigate the potential of these non-coding RNAs as biomarkers for early detection, prognosis, and predictors of therapeutic response.
4. Stimulate the development of innovative therapeutic strategies that target circRNAs and miRNAs in NSCLC.
Please note manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases that are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of the scope of this Research Topic.
The key to improving the current diagnostic and therapeutic approaches for NSCLC lies in understanding the role of circular RNAs and microRNAs in carcinogenesis and cancer progression. Despite their potential, there are no validated circular RNA- or microRNA-derived biomarkers for diagnosis, nor are there any circular RNAs and microRNAs that can be used for targeted therapeutics. This underscores the urgency and importance of the research in this field.
Furthermore, the discovery of non-coding RNAs has significantly altered our understanding of the molecular underpinnings of cancer. CircRNAs and miRNAs have been identified as crucial regulators in numerous cellular processes, including proliferation, apoptosis, and metastasis. However, their roles in NSCLC are not fully understood, and the clinical applications of this knowledge are still in the early stages. This Research Topic seeks to bridge these gaps by highlighting the latest research and encouraging interdisciplinary collaborations. We aim to catalyze breakthroughs in NSCLC diagnosis, prognosis, and therapeutic interventions by addressing these gaps.
We invite molecular biology, oncology, and translational medicine researchers to contribute to this Research Topic. Potential submissions include original research, comprehensive review articles, and perspectives, among other types of articles. We particularly welcome studies that provide insights into the molecular mechanisms, potential clinical applications, and therapeutic innovations concerning circRNAs and miRNAs in NSCLC.
The contributions to this Research Topic are expected to advance our understanding of NSCLC at a molecular level, promoting the development of novel diagnostic and therapeutic tools. This collection of articles is anticipated to enhance current treatment paradigms and set a new direction for future research and clinical practices related to NSCLC. By providing a platform for the latest research in circRNAs and miRNAs in NSCLC, this Research Topic will foster significant advancements and inspire ongoing investigations into their potential to change the landscape of cancer therapy.
The objectives of this Research Topic are to:
1. Highlight novel research on the biogenesis and function of circRNAs and miRNAs in NSCLC.
2. Explore the association of circRNAs and miRNAs with tumor progression, metastasis, and resistance to current treatments.
3. Investigate the potential of these non-coding RNAs as biomarkers for early detection, prognosis, and predictors of therapeutic response.
4. Stimulate the development of innovative therapeutic strategies that target circRNAs and miRNAs in NSCLC.
Please note manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases that are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of the scope of this Research Topic.
Keywords: Circular RNA; MicroRNA; Lung Cancer; Biomarker; Cancer Therapy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
