About this Research Topic
Ototoxicity, characterized by hearing loss and other auditory disturbances, is a significant adverse effect associated with various medications, such as aminoglycosides, loop diuretics, and notably cisplatin, which is widely utilized in chemotherapy. This condition not only diminishes the quality of life for affected individuals but also poses a considerable public health challenge. The widespread impact of drug-induced ototoxicity underscores the urgent need for effective prevention and therapeutic strategies. This Research Topic aims to delve into the intricate mechanisms of drug-induced ototoxicity and explore innovative approaches for its prevention and treatment.
The primary goal of this Research Topic is to enhance our understanding of the mechanisms underlying drug-induced ototoxicity and to identify potential therapeutic targets for intervention. This effort aspires to facilitate the development of effective clinical solutions that can prevent or mitigate the adverse auditory effects of ototoxic drugs.
This Research Topic invites a broad spectrum of studies and reviews related to drug-induced ototoxicity, aiming to provide a multidisciplinary perspective on this critical issue. Contributions may include, but are not limited to, the following themes:
• Investigate the morphological changes and pathological basis of drug-induced ototoxicity.
• Explore the biological mechanisms and pathways, including inflammation, immune responses, and cytokine signaling, that contribute to ototoxicity.
• Evaluate the protective effects and underlying mechanisms of drugs designed to alleviate ototoxicity, identifying new therapeutic targets.
• Review existing literature on drugs with known ototoxicity-alleviating properties and their mechanisms of action.
This Research Topic welcomes various types of manuscript submissions including Original Research, Review, Mini Review, Research Report, and Perspective. By consolidating comprehensive and pioneering studies, we aim to drive forward the understanding and management of drug-induced ototoxicity, ultimately contributing to improved therapeutic strategies and patient outcomes.
The primary goal of this Research Topic is to enhance our understanding of the mechanisms underlying drug-induced ototoxicity and to identify potential therapeutic targets for intervention. This effort aspires to facilitate the development of effective clinical solutions that can prevent or mitigate the adverse auditory effects of ototoxic drugs.
This Research Topic invites a broad spectrum of studies and reviews related to drug-induced ototoxicity, aiming to provide a multidisciplinary perspective on this critical issue. Contributions may include, but are not limited to, the following themes:
• Investigate the morphological changes and pathological basis of drug-induced ototoxicity.
• Explore the biological mechanisms and pathways, including inflammation, immune responses, and cytokine signaling, that contribute to ototoxicity.
• Evaluate the protective effects and underlying mechanisms of drugs designed to alleviate ototoxicity, identifying new therapeutic targets.
• Review existing literature on drugs with known ototoxicity-alleviating properties and their mechanisms of action.
This Research Topic welcomes various types of manuscript submissions including Original Research, Review, Mini Review, Research Report, and Perspective. By consolidating comprehensive and pioneering studies, we aim to drive forward the understanding and management of drug-induced ototoxicity, ultimately contributing to improved therapeutic strategies and patient outcomes.
Keywords: ototoxicity, hearing loss, drug-induced toxicity, aminoglycosides, cisplatin, therapeutic targets, protective agents, auditory health
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
