The exploration of biomarkers in trauma and critical care is a rapidly evolving field, with a particular focus on cellular and vesicular biomarkers linked to immunity. Trauma remains a leading cause of death worldwide, especially among young individuals, highlighting the urgent need to understand the complex interactions between the immune system and trauma outcomes. While traditional biomarkers such as albumin, creatinine kinase, and cytokines have been associated with trauma, recent studies suggest that microRNAs and extracellular vesicles may offer more specific insights into trauma-related changes. These novel markers, detectable in body fluids like blood, urine, and cerebrospinal fluid, provide a non-invasive approach to assessing trauma impact. However, the role of the immune system in this context is still not fully understood, necessitating further investigation into cellular, metabolic, and vesicular components to better comprehend the immune system's involvement in traumatic injuries.
This research topic aims to investigate specific biomarkers that can serve as indicators of trauma severity, potential complications, and prognosis, with a focus on the crucial role of host immunity in responding to traumatic injuries. By identifying and understanding these novel markers, the research community seeks to develop refined strategies for risk assessment, tailored treatment approaches, and timely surgical interventions. The ultimate objective is to optimize outcomes for individuals affected by severe trauma by advancing the scientific community's understanding of the immune system's role in trauma and care.
To gather further insights into the immune mechanisms involved in trauma, we welcome articles addressing, but not limited to, the following themes:
- Identification and validation of novel cellular and vesicular biomarkers in trauma.
- The role of microRNAs and extracellular vesicles in trauma-related immune responses.
- Non-invasive methods for assessing trauma impact through body fluids.
- The interplay between metabolic changes and immune responses in trauma.
- Development of risk assessment tools and treatment strategies based on biomarker insights.
- Clinical applications and implications of immune-related biomarkers in trauma management.
Keywords: Trauma, Biomarkers, Immunity, Cellular, Vascular
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
