Herpesviruses: Pathogenesis and Host Interactions

Herpesviruses form an intricate part of viral pathology, affecting a broad range of species through complex mechanisms of interaction with host biological systems. These interactions are central not only to disease manifestation but also to the intriguing potential for cross-species infections as revealed by recent molecular studies. Further, research delving into the role of microRNAs in the viral pathogenesis and immune responses, particularly in specialized contexts, has underlined the adaptability of herpesviruses as well as the host’s defensive and sometimes pathogenic responses.

This Research Topic aims to broaden the understanding of herpesvirus pathogenesis, host interactions, and their implications for treatment modalities. Studies are particularly encouraged to investigate subtle genetic exchanges between virus and host that may illuminate novel antiviral strategies or point to vulnerabilities in current treatment frameworks.

To gather further insights in the multifaceted nature of herpesviruses and their treatment, we welcome articles addressing, but not limited to, the following themes:

Cross-species herpesvirus infection and its molecular basis

MicroRNA functions in herpesvirus lifecycle and pathogenicity

Immune response mechanisms to herpesviruses and systemic as well as localized infections.

Recent advancements in herpesvirus treatment options and the development of novel therapeutics

Associations between Herpesviruses and systemic, chronic, or novel diseases

Effects of Herpesviruses on pathogenic changes in the host microbiota

Effects of host metabolism on herpesviruses for life-cycle and pathogenesis

Cross-talk between herpesviruses and endothelial cells

Keywords: Herpesvirus, Host biological processes, Cross-species infection, MicroRNAs, Treatment strategies

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.