Skin Microbiome: Microbiological, Immunological and Cellular aspects for therapies to control Antimicrobial Resistance and Skin Repair

The skin, a crucial barrier and the largest organ in the human body, serves as the first line of defense against external threats by hosting a complex ecosystem of microorganisms, including bacteria and fungi. This skin microbiome is integral to health and disease, collaborating with the immune system through biochemical signaling. Dysregulation of this microbiome can lead to various local and systemic pathologies, supporting a broader understanding of its impact on general health, including its potential connection to intestinal health. Emerging research even suggests that this intricate microbial landscape may influence conditions ranging from skin infections to systemic immune disorders.

This Research Topic aims to deepen our understanding of the skin microbiome's essential functions in health and disease, particularly its role in the global challenge of antimicrobial resistance. With resistance posing a significant and escalating threat to public health, comprehending how the skin microbiome contributes to and could potentially mitigate this crisis is critical. Through focused studies, we look to uncover the interactions between the microbiome and host immune responses and explore innovative therapeutic strategies.

To gather further insights in this critical area of research, we welcome articles addressing, but not limited to, the following themes:
- Variations in the skin microbiome across health and disease states
- The skin's interaction with pathogens and its impact on immune functions
- Development of new treatments for epithelial care and microbial control
- Comprehensive analyses of skin microbiota in health and disease
- Discrimination of the proportion of bacterial/fungal species in the context of pathology
- Studies that evaluate the bacterial/fungal/host interaction in the context of the immune system
- Developing therapeutic options for antimicrobial control/skin asepsis
- Challenges in current diagnostic methods for assessing the skin microbiome

Submissions of Original Research, Reviews, and Mini Reviews are particularly encouraged to contribute to this evolving field.

Keywords: Microbiology, Immunology, Antimicrobial agents, Antimicrobial resistance, Antimicrobial Photodynamic Therapy, antimicrobial biomaterials, Probiotics, Phytotherapy, Drug Repositioning, Skin Abnormalities, Gut-brain-skin axes, Skin wound

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.