Molecular mechanisms and clinical studies of multi-organ dysfunction in sepsis associated with pathogenic microbial infection

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ORIGINAL RESEARCH

Published on 05 Dec 2025

The non-linear association between creatinine-to-albumin ratio and medium-term mortality in patients with sepsis accompanied by acute kidney injury in the intensive care unit: a retrospective study based on the MIMIC database and external validation

Jiaqi Lou
Ziyi Xiang
Xiaoyu Zhu
Jingyao Song
Shengyong Cui
Jiliang Li
Sida Xu
Neng Huang
Xin Le
1 more
Guoying Jin

doi 10.3389/fcimb.2025.1602921

581 views

ORIGINAL RESEARCH

Published on 10 Nov 2025

The accuracy of heparin-binding protein and interleukin-6 in predicting prognosis of severe pneumonia with sepsis patients

Zhiyong Wei
Maimaitijiang YuSuPu
Xiaoye Wang
Yu Meng
Chunli Zhang
Xiaomeng Xue
Yan Cui
Keliang Xie

doi 10.3389/fcimb.2025.1554214

1,002 views

ORIGINAL RESEARCH

Published on 29 Jul 2025

The predictive value of SOFA and APSIII scores for 28-day mortality risk in SIMI: a cohort study based on the MIMIC-IV database

Chang Liu
Hao Wang
Chenyang Liu
Min Cao

doi 10.3389/fcimb.2025.1574625

1,625 views
1 citation

ORIGINAL RESEARCH

Published on 28 Jul 2025

LILRA5+ macrophages drive early oxidative stress surge in sepsis: a single-cell transcriptomic landscape with therapeutic implications

Peng Xu
Haoze Li
Zuo Tao
Zixuan Zhang
Xiaohuan Wang
Cheng Zhang

doi 10.3389/fcimb.2025.1606401

1,641 views

ORIGINAL RESEARCH

Published on 22 Jul 2025

MicroRNA-27b alleviates septic cardiomyopathy by targeting the Mff/MAVS axis

Xincai Wang
Long Huang
Jingqing Xu
Min Li
Hongxuan Zhang
Yuqing Yao
Yaqing Liu
Xingsheng Lin
Xiuling Shang

doi 10.3389/fcimb.2025.1588461

1,773 views

ORIGINAL RESEARCH

Published on 22 Jul 2025

The J-shaped association between the ratio of neutrophil counts to prognostic nutritional index and mortality in ICU patients with sepsis: a retrospective study based on the MIMIC database

Jiaqi Lou
Hong Kong
Ziyi Xiang
Xiaoyu Zhu
Shengyong Cui
Jiliang Li
Guoying Jin
Neng Huang
Xin Le
1 more
Sida Xu

doi 10.3389/fcimb.2025.1603104

2,042 views
2 citations

REVIEW

Published on 08 Jul 2025

Gut microbiota and sepsis-associated encephalopathy: pathogenesis and precision therapies

Na Wei
Shiyu Dai
Wei Li
Jun Zhou
Ye Chen

doi 10.3389/fnins.2025.1596467

2,981 views

ORIGINAL RESEARCH

Published on 11 Jun 2025

Enhancing sepsis management: the role of dynamic heparin-binding protein monitoring in elderly patients

Lei Miao
Dandan Liu
Jingxian Liao
Xiaozhu Shen
Chunhui Xie
Guangyun Hu

doi 10.3389/fmed.2025.1538515

1,124 views

ORIGINAL RESEARCH

Published on 09 Jun 2025

A multi-omics study of magnesium sulfate to improve prognosis in sepsis-related encephalopathy: integrating clinical data-driven network pharmacology

Yingming Kong
Yanghao Tai
Bin Chen
Meng Zhang
Haoyu Ji
Rongke Feng
Liang Shi
Hao Chen

doi 10.3389/fcimb.2025.1607586

4,016 views

ORIGINAL RESEARCH

Published on 06 Jun 2025

A machine learning model for robust prediction of sepsis-induced coagulopathy in critically ill patients with sepsis

Jia Sun
Lixin Zhang
Zhaotang Gong
Hongling Ma
Dan Wu
Rihan Wu
Guleng Siri

doi 10.3389/fcimb.2025.1579558

3,882 views
2 citations

ORIGINAL RESEARCH

Published on 15 May 2025

Characteristics and prognosis of patients with pathogenic microorganism-positive sepsis AKI from ICU: a retrospective cohort study

Panpan Jin
Xihan Meng
Chao Yu
Cong Zhou

doi 10.3389/fcimb.2025.1509180

1,737 views

REVIEW

Published on 13 May 2025

The progress of the microbe-gut-brain axis in sepsis-associated encephalopathy

Chen He
Hui Shi
Zhijie Yu
Chunhan Ma
Zhiqiang Jiao
Jin Li
Fei Yang

doi 10.3389/fcimb.2025.1587463

3,280 views
1 citation

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Frontiers in Cellular and Infection Microbiology

Clinical Infectious Diseases

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Articles

The non-linear association between creatinine-to-albumin ratio and medium-term mortality in patients with sepsis accompanied by acute kidney injury in the intensive care unit: a retrospective study based on the MIMIC database and external validation

The accuracy of heparin-binding protein and interleukin-6 in predicting prognosis of severe pneumonia with sepsis patients

The predictive value of SOFA and APSIII scores for 28-day mortality risk in SIMI: a cohort study based on the MIMIC-IV database

LILRA5+ macrophages drive early oxidative stress surge in sepsis: a single-cell transcriptomic landscape with therapeutic implications

MicroRNA-27b alleviates septic cardiomyopathy by targeting the Mff/MAVS axis

The J-shaped association between the ratio of neutrophil counts to prognostic nutritional index and mortality in ICU patients with sepsis: a retrospective study based on the MIMIC database

Gut microbiota and sepsis-associated encephalopathy: pathogenesis and precision therapies

Enhancing sepsis management: the role of dynamic heparin-binding protein monitoring in elderly patients

A multi-omics study of magnesium sulfate to improve prognosis in sepsis-related encephalopathy: integrating clinical data-driven network pharmacology

A machine learning model for robust prediction of sepsis-induced coagulopathy in critically ill patients with sepsis

Characteristics and prognosis of patients with pathogenic microorganism-positive sepsis AKI from ICU: a retrospective cohort study

The progress of the microbe-gut-brain axis in sepsis-associated encephalopathy

Frontiers in Cellular and Infection Microbiology

Clinical Infectious Diseases