Transgenerational Effects of Endocrine Disrupting Chemicals: Unraveling Hormonal and Health Impacts Across Generations

Endocrine-disrupting chemicals (EDCs) are increasingly recognized as a significant concern for public health due to their propensity to interfere with the endocrine system. These chemicals are implicated in a variety of adverse effects, from immediate health issues to more delayed and insidious outcomes. Recent research has highlighted their potential to cause transgenerational effects, meaning they not only affect individuals directly exposed but also succeeding generations. This has raised deep concerns about long-term impacts on hormonal regulation, reproductive health, and development. Unraveling the mechanisms behind these effects, which may include epigenetic modifications and shifts in gene expression, is crucial yet challenging, indicating a significant gap in our current understanding of these phenomena.

This Research Topic aims to delve into the intricate and underexplored pathways through which EDCs impact health across generations. The primary objective is to elucidate the mechanisms—particularly epigenetic changes and gene expression alterations—that mediate these long-term effects. By integrating recent advances from fields such as molecular biology, toxicology, and epidemiology, this Topic aims to provide a clearer picture of how these substances disrupt health across generations, fostering more effective interventions and informing policy.

To gather further insights into the complexities of EDCs, this Research Topic will focus on:
o Epigenetic Modifications: Investigating how EDCs induce changes in DNA methylation, histone modification, and non-coding RNA expression across generations.
o Gene Expression Alterations: Exploring the alteration of gene expression by EDCs and consequent long-term effects on endocrine health.
o Reproductive Health Impacts: Examining the influence of EDCs on fertility, developmental health of reproductive organs, and hormonal balance through generations.
o Developmental and Growth Disruptions: Assessing the impact of EDCs on physical and neurological development during vulnerable stages.
o Critical Windows of Susceptibility: Identifying critical exposure periods to EDCs, including prenatal, perinatal, and early childhood stages.
o Mitigation and Policy Implications: Discussing strategies for reducing exposure to EDCs and exploring policy measures necessary for effective public health protection.