New Advancement in Tumor Microenvironment Remodeling and Cancer Therapy, Volume II

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ORIGINAL RESEARCH

Published on 29 Sep 2025

Single-cell and bulk RNA-sequencing reveal PRRX2-driven cancer-associated fibroblast-mediated perineural invasion for predicting the immunotherapy outcome in colorectal cancer

Mingxiao Chen
Yue Cai
Feng Han
Bo Li
Zhou Xu
Kaili Cui
Wenqi Bai
Feng Li

doi 10.3389/fcell.2025.1620388

401 views

ORIGINAL RESEARCH

Published on 07 Aug 2025

MiR-145-5p arrests the cell cycle by modulating SMAD5/cyclin D1 to inhibit gastric cancer progression

Li Wang
Jianghong Guo
Caixia Lv
Luke Kong
Jing Cui
Zhongshuai Wang
Yuanyuan Guo
Ruirui Jia
Tao Guan
1 more
Feng Li

doi 10.3389/fcell.2025.1619359

824 views

ORIGINAL RESEARCH

Published on 11 Jul 2025

Aurora kinase-a expression heterogeneity and potential benefit of combination therapy in prostate adenocarcinoma

Ru Chen
Qianyi Qiu
Weiting Xie
Jun Lin
Rong Liu
Jianhui Chen
Shaoxing Zhu
Yiming Su

doi 10.3389/fcell.2025.1608711

1,401 views

ORIGINAL RESEARCH

Published on 09 Jul 2025

Comprehensive fragmentation of cell-free repetitive DNA for enhanced cancer detection in plasma

Mingguang Zhang
Shuohui Dong
Wei Rao
Shiwen Mei
Gang Hu
Ling Liu
Zhen Wang
Jianqiang Tang

doi 10.3389/fcell.2025.1630231

1,578 views

REVIEW

Published on 16 Apr 2025

Extracellular vesicles: messengers of cross-talk between gastric cancer cells and the tumor microenvironment

Xiwen Li
Xian Lu
Mi Liu
Junjie Chen
Xirong Lu

doi 10.3389/fcell.2025.1561856

1,604 views
1 citation

REVIEW

Published on 09 Apr 2025

Gemcitabine: immunomodulatory or immunosuppressive role in the tumor microenvironment

Mahnaz Nemati
Chou-Yi Hsu
Deepak Nathiya
M. Ravi Kumar
Enwa Felix Oghenemaro
Muthena Kariem
Parjinder Kaur
Deepak Bhanot
Ahmed Hjazi
Tayebeh Azam Saedi

doi 10.3389/fimmu.2025.1536428

2,618 views

ORIGINAL RESEARCH

Published on 20 Jan 2025

Hypoxia signature derived from tumor-associated endothelial cells predict prognosis in gastric cancer

Ruiheng Wang
Guijun Liu
Ke Wang
Zhanglei Pan
Zhihua Pei
Xijiao Hu

doi 10.3389/fcell.2025.1515681

1,398 views
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Cancer Cell Biology

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Articles

Single-cell and bulk RNA-sequencing reveal PRRX2-driven cancer-associated fibroblast-mediated perineural invasion for predicting the immunotherapy outcome in colorectal cancer

MiR-145-5p arrests the cell cycle by modulating SMAD5/cyclin D1 to inhibit gastric cancer progression

Aurora kinase-a expression heterogeneity and potential benefit of combination therapy in prostate adenocarcinoma

Comprehensive fragmentation of cell-free repetitive DNA for enhanced cancer detection in plasma

Extracellular vesicles: messengers of cross-talk between gastric cancer cells and the tumor microenvironment

Gemcitabine: immunomodulatory or immunosuppressive role in the tumor microenvironment

Hypoxia signature derived from tumor-associated endothelial cells predict prognosis in gastric cancer

Frontiers in Cell and Developmental Biology

Cancer Cell Biology