What's on the Horizon for Asthma Treatment?

Asthma continues to be a prevalent chronic inflammatory disorder characterized by unpredictable exacerbations that severely affect the individual's quality of life, leading to significant healthcare costs and productivity losses. Despite the availability of multiple treatment options, the global burden of asthma in terms of morbidity and mortality remains substantial. Advances in understanding the pathophysiology of asthma have led to the development of innovative and targeted treatment modalities that could potentially transform current therapeutic approaches and improve patient outcomes.

This Research Topic aims to explore the future of asthma treatment by investigating emerging therapies, incorporating personalized medicine, and evaluating innovative non-pharmacological strategies. The goal is to identify how recent advancements can be tailored to individual patient profiles to improve the efficacy of existing management practices. Furthermore, we aim to assess the potential of artificial intelligence in refining disease phenotypes and optimizing therapeutic strategies, especially in the context of biological treatments and severe asthma comorbidities such as COPD and polyposis.

To gather further insights in defining a more effective asthma treatment paradigm, we welcome articles addressing, but not limited to, the following themes:

- The impact of gender differences on the treatment and management of asthma, including variations in prevalence and severity across genders.
- The intersection of asthma with comorbid conditions like Sleep Breathing Disorders, particularly how Obstructive Sleep Apnea interacts with asthma and affects treatment outcomes.
- Emerging biologics and their role in managing severe asthma, focusing on how these new treatments can be tailored to patient-specific disease phenotypes.
- Precision medicine approaches in asthma treatment that utilize detailed phenotyping and genotyping to guide therapy choices.
- Genetic and epigenetic targets for developing novel asthma therapies that could revolutionize treatment regimens.
- The potential of microbiome modulation as a therapeutic strategy, examining how gut-lung interactions influence asthma and its management.
- Advances in smart inhalers and the integration of digital health technologies that could enhance monitoring and compliance.
- Challenges and opportunities in translating these novel therapies into clinical practice, ensuring they are accessible and effective in real-world settings.
- The prospect of gene therapy and small molecule inhibitors in asthma management, exploring their potentials and challenges in clinical applications.
- The role of emerging biomarkers in identifying and monitoring asthma and its comorbidities.


Topic Editor Mauro Maniscalco has received research grants from AstraZeneca and GlaxoSmithKline, paid to Istituti Clinici Scientifici Maugeri. He has received payments for presentations or educational events from GlaxoSmithKline, Chiesi, and Damor Farmaceutici. Additionally, he participates in advisory boards for GSK and AstraZeneca.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Case Report
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Case Report
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Technology and Code

Keywords: Asthma, Precision Medicine in Respiratory Care, Gender Differences in Asthma, Comorbid Sleep Disorders, Obstructive Sleep Apnea and Asthma, Clinical Translation of Asthma Treatments

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.