Cardiovascular Dysfunction in PCOS: Mitochondrial and Inflammatory Mechanisms

Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder that affects metabolic and cardiovascular health, posing a significant risk for long-term cardiovascular complications. Women with PCOS often exhibit insulin resistance, dyslipidemia, and systemic inflammation, which contribute to mitochondrial dysfunction and metabolic inflexibility - key factors in the development of cardiovascular disease (CVD). These disturbances are associated with increased risks of hypertension, cardiac fibrosis, and endothelial dysfunction in PCOS patients.

This research topic focuses on the cardiovascular consequences of PCOS, specifically exploring the molecular mechanisms that drive cardiovascular dysfunction in this population. By investigating mitochondrial impairment, chronic inflammation, and metabolic dysregulation, the aim is to better understand the cardiovascular risks associated with PCOS and identify potential therapeutic strategies.

This research topic aims to foster a deeper understanding of the mechanisms driving cardiovascular dysfunction in PCOS, highlighting innovative strategies for prevention and treatment. By focusing on mitochondrial and inflammatory pathways, this topic will contribute to improving cardiovascular outcomes in women with PCOS.

In this Research Topic, we invite contributors to submit papers on the following topics, including but not limited to:

• Mitochondrial dysfunction as a driver of cardiovascular disease in PCOS.

• Chronic inflammation and its contribution to cardiac fibrosis and vascular dysfunction in PCOS.

• Metabolic dysregulation and its impact on cardiovascular outcomes in PCOS.

• Therapeutic potential of modulators such as short-chain fatty acids and HDAC inhibitors in mitigating cardiovascular risk in PCOS.

• Role of systemic insulin resistance and dyslipidemia in cardiovascular health in PCOS.

• Cross-talk between adipose tissue and the cardiovascular system in PCOS-related cardiometabolic dysfunction.

• Novel interventions targeting mitochondrial dysfunction and inflammation in cardiovascular disease associated with PCOS.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Clinical Trial
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Clinical Trial
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Policy and Practice Reviews
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: Polycystic ovary syndrome (PCOS), cardiovascular disease (CVD), mitochondrial dysfunction, chronic inflammation, metabolic dysregulation, insulin resistance, dyslipidemia, cardiac fibrosis, vascular dysfunction, therapeutic interventions

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.