Interplay of Inflammation and Schizophrenia: Pathophysiology and Therapeutic Opportunities

Schizophrenia is a chronic psychiatric disorder, characterized by profound impact on cognitive and emotional functioning. A significant body of research identifies disturbances in the immune system as a recurring theme in schizophrenia patients, particularly noting deviations in crucial immune molecules and cellular components. These alterations are increasingly correlated with variances in cognitive abilities, alterations in brain structure, and varied responses to pharmacological treatments.

This Research Topic aims to explore the potential mechanisms through which inflammation is interconnected with schizophrenia symptoms. The aim is to better understand how inflammatory processes contribute to the pathophysiology of the disorder and how this knowledge can be used to help enhance patient outcomes. Crucially, the goal is to uncover whether targeted anti-inflammatory strategies can provide therapeutic benefits.

To gather further insights in this area we welcome contributions including, but not limited to, the following themes:

- Mechanistic studies on inflammation-schizophrenia 
- Impact of immune response alterations on schizophrenia symptoms
- New insights from pre-clinical models of schizophrenia
- Clinical trials targeting inflammation in schizophrenia
- Reviews and meta-analyses evaluating existing research on inflammation and schizophrenia

Note: This Research Topic welcomes submission of all types of articles including original research, review, mini-review, hypothesis and theory, perspective and opinion.