Innovative Molecular Strategies for Allergy Management

Allergic diseases pose a significant global health challenge, affecting up to 40% of the global population. These diseases are primarily driven by an immune response mediated by allergen-specific immunoglobulin E (sIgE), leading to both immediate and late phase responses that can escalate to life-threatening conditions such as anaphylaxis, as well as chronic inflammation. Currently, available treatments mainly offer symptomatic relief and often fail to alter the underlying allergenic response. Moreover, existing immunotherapies carry risks, including potential anaphylactic reactions. There is a critical need for novel therapeutic strategies that can accurately target and modulate the immune mechanisms underlying allergic diseases, offering more personalized and effective treatments.

This Research Topic aims to explore new molecular approaches for modifying the immune responses associated with allergic diseases to develop safer, more effective therapies. The focus is on identifying and utilizing molecular targets that can shift the allergen-specific immune response towards a non-harmful profile. This encompasses advances from omics technologies, which enhance our understanding of allergens and allergic responses, and facilitate the development of innovative treatments like DNA/RNA vaccines, and targeted monoclonal antibody therapies.

To gather further insights in this evolving area of allergy treatment, we welcome articles addressing, but not limited to, the following themes:

-Molecular strategies to identify treatment responders with specific markers
-Use of recombinant allergens and hypoallergenic variants in immunotherapy
-Proteomics and peptide-based approaches to immunotherapy
-Novel allergen delivery systems and adjuvants for allergen-specific immunotherapy
-Development and application of new monoclonal antibodies targeting allergy-related molecules
-The role of DNA and mRNA vaccines in managing allergic diseases
-RNAi and antisense RNA therapies targeting allergic pathways
-Applications and challenges of CRISPR technology in allergy treatment