Pharmacological and Nutritional Approaches to Metabolic Associated Fatty Liver Disease: A Step Towards Achieving SDG 3

Metabolic Associated Fatty Liver Disease (MAFLD) has emerged as a global public health concern due to its increasing prevalence and association with obesity, type 2 diabetes, and cardiovascular diseases. As a multifaceted condition, MAFLD involves complex metabolic and inflammatory pathways, posing significant challenges for prevention and management. Current research underscores the importance of both pharmacological and nutritional interventions in mitigating disease progression and improving patient outcomes.

This Research Topic aims to explore innovative approaches to MAFLD, with a focus on pharmacological treatments and nutritional strategies that align with Sustainable Development Goal 3 (SDG 3): ensuring healthy lives and promoting well-being for all at all ages. We welcome original research, reviews, clinical trials, and perspectives that advance our understanding of the interplay between nutrition, pharmacology, and metabolic health.

This Research Topic aims to address the critical need for innovative and integrative strategies in the management of Metabolic Associated Fatty Liver Disease (MAFLD) by emphasizing the potential for a combined approach involving pharmacological and nutritional interventions. A promising area of research for improving metabolic health and liver function is to further understand the relationship between pharmacological agents and evidence-based dietary strategies. By integrating these disciplines, this initiative aims to identify and advance targeted therapeutic approaches, dietary patterns, bioactive compounds, and lifestyle interventions that could alleviate the burden of MAFLD.

This Research Topic invites contributions that explore pharmacological and nutritional approaches to the prevention and management of Metabolic Associated Fatty Liver Disease (MAFLD). Submissions may focus on a wide range of themes, including but not limited to:
• Mechanistic insights into the role of pharmacological agents in hepatic metabolism, inflammation, and fibrosis.
• Nutritional therapies, such as the impact of dietary patterns (e.g., Mediterranean diet, plant-based diets) and bioactive compounds (e.g., polyphenols, omega-3 fatty acids) on liver health.
• Drug-nutrient interactions and their implications for personalized medicine in MAFLD management.
• Clinical trials assessing the efficacy of combined pharmacological and nutritional interventions.
• The role of the gut-liver axis and microbiota modulation in MAFLD progression.
• Lifestyle interventions targeting metabolic health and their long-term outcomes.

We welcome original research, reviews, mini-reviews, clinical studies, systematic reviews, meta-analyses, and perspectives that align with these themes. Contributions should aim to advance understanding and provide innovative solutions to reduce the global burden of MAFLD.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: Metabolic Associated Fatty Liver Disease (MAFLD), Non-Alcoholic Fatty Liver Disease (NAFLD), Liver Metabolism, Pharmacological Interventions, Nutritional Therapy, Functional Foods

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.