RNA applications in cardiometabolic diseases

The era of RNA research has recently become the subject of prominent attention as several scientists from RNA research field have received the Nobel Prizes in Physiology and Medicine in 2023 and 2024. The speed of the development and the success of mRNA vaccines during COVID-19 significantly demonstrate the efficacy of RNA-based approaches and highlight the tremendous potential of RNA therapeutics.

RNAs are structurally diverse and functionally specific molecules with significant potential for diagnostic and therapeutic use. RNA molecules can function as a code for protein synthesis, suppress protein expression, and can have catalytic activity as enzymes. These RNA characteristics are the foundation for development of many FDA approved RNA-based drugs like Inclisiran.

This Research Topic aims to explore the use of RNA molecules in the diagnosis and treatment of cardiometabolic diseases, highlighting their potential as both diagnostics and therapeutics. It will focus on emerging technologies that enhance RNA functionality, stability, and localization, which are crucial for their clinical applications.

To further our exploration of RNA in cardiometabolic diseases, we welcome contributions focusing on the following refined themes:

•Investigative studies on the use of various RNA molecules as diagnostic and therapeutic tools in cardiometabolic diseases.
•Meta-analysis and the application of AI for RNA-seq data and network medicine approaches to identify disease-associated pathways.
•Advances in RNA synthesis, design, and structural modifications to improve diagnostic and therapeutic outcomes.

Cardiovascular and Smooth Muscle Pharmacology welcomes submissions of the following article types: Brief Research Report, Case Report, Correction, Editorial, General Commentary, Hypothesis & Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Review, Technology and Code.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Technology and Code

Keywords: RNA therapeutics, cardiometabolic diseases, RNA-seq technologies, network medicine, therapeutic targets, RNA-based diagnostics, cardiometabolic disorders, mRNA vaccines, therapeutic RNA, immuno-metabolic pathways

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.