Exploring Molecular Mechanisms in Cancer through Tumor Molecular Pathology

Tumor molecular pathology is an evolving field dedicated to uncovering the molecular underpinnings of cancer development and progression. This discipline merges traditional histopathological techniques with advanced molecular biology methods, including next-generation sequencing, microarray analysis, and single-cell profiling. By pinpointing genetic, epigenetic, and proteomic changes within tumors, it links molecular characteristics with clinical outcomes, supporting more precise cancer diagnoses, prognostication, personalized treatment approaches, and the identification of novel therapeutic targets. Continued advancements have expanded our understanding of cancer genomics, epigenomics, proteomics, and the tumor microenvironment—key factors in cancer initiation, metastasis, immune response, and resistance to therapy.

This Research Topic aims to establish a comprehensive platform that solidifies the foundation of tumor molecular pathology as an integral part of cancer diagnosis and treatment. Its primary objectives are to delve into the molecular basis of tumor behavior, explore the translational potential of molecular findings, and advance molecular diagnostic tools, biomarkers, and targeted treatment strategies. With a spotlight on molecular diagnostics and the pivotal role they play in enhancing cancer detection, treatment stratification, and disease monitoring, the goal is to foster innovative approaches in molecularly targeted therapies, immunotherapies, and personalized medicine, significantly contributing to the transformative progress in cancer therapy.

To gather further insights within the defined boundaries of tumor molecular pathology, we welcome articles addressing, but not limited to, the following themes:

o Molecular Pathways in Cancer

o Immunotherapy and Immune Profiling

o Molecular Diagnostics and Biomarkers

o Targeted Therapy and Personalized Medicine

o Tumor Microenvironment

o Cancer Evolution and Metastasis

By facilitating the exchange of ideas and fostering collaborations among researchers, clinicians, and pharmaceutical companies, this Research Topic aims to accelerate the transition of research discoveries into meaningful clinical applications.




Please note that manuscripts consisting solely of bioinformatics or computational analysis of public omics databases that are not supplemented by relevant functional validation (clinical cohort or biological validation, in vitro or in vivo) are out of scope for this Research Topic.

Keywords: Cancer, Pathology, Molecular Biology, Tumor Immunology, Cell Signaling, Cell Apoptosis, Cell Proliferation, Cell Cycle

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.