Regulated cell death and neurological diseases

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Background

Several forms of regulated cell death (RCD), which include necroptosis, pyroptosis, parthanatos, ferroptosis, cuproptosis, lysozincrosis and disulfdptosis, et.al. have been uncovered during the past two decades. Dysregulation of RCD, a critical for the development and homeostasis of almost all multicellular organisms, leads to neurological diseases. However, the role of RCD in different neurological diseases is still in its infancy. It is crucial to determine the detailed mechanisms underlying these RCD plays a role in the pathogenesis of neurological diseases. Accumulating evidence supports pharmacological modulation of RCD as a therapeutic target for neurological diseases.

The aims of this Research Topic are:

(1) To delineate the role of RCD in various neurological diseases.

(2)To uncover the novel therapy regimen by targeting these RCD in neurological diseases.

We welcome submissions of Original Research, Reviews, Mini-Reviews, and Systematic Reviews that explore a wide range of topics, including, but not limited to, the following:

• How dysregulation of RCD leads to the pathogenesis of neurological diseases.

• How Epigenetic and post-translational modifications regulate RCD to cause neurological diseases.

• How the interplay of different RCD contributes to neurological diseases.

• How the interplay of cell signaling pathway, such as cGAS-STING, JAK-STAT with different RCD contributes to neurological diseases.

• Strategies for targeting RCD to treat neurological diseases.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Brief Research Report
  • Case Report
  • Conceptual Analysis
  • Data Report
  • Editorial
  • FAIR² Data
  • General Commentary
  • Hypothesis and Theory
  • Methods

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Brief Research Report
  • Case Report
  • Conceptual Analysis
  • Data Report
  • Editorial
  • FAIR² Data
  • General Commentary
  • Hypothesis and Theory
  • Methods
  • Mini Review
  • Opinion
  • Original Research
  • Perspective
  • Registered Report
  • Review
  • Study Protocol
  • Systematic Review
  • Technology and Code

Keywords: regulated cell death, pyroptosis, ferroptosis, cuproptosis, neurological diseases

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