In the intricate regulation of inflammation, metabolic reprogramming and posttranslational modification (PTM) have emerged as pivotal players, offering new avenues for understanding the fine-tuned molecular mechanisms governing immunology. Metabolic reprogramming is a fundamental adaptation that immune cells undergo to meet the heightened energy and biosynthetic demands during an immune response. This reprogramming involves shifts in metabolic pathways, leading to the production of various metabolites that can serve as substrates or signaling molecules. For example, recently identified lactylation occurs when lactate, a metabolite that accumulates during the respiratory burst in immune cells, covalently modifies proteins. This modification can alter the function, localization, or stability of the targeted proteins, thereby modulating the inflammatory response. The discovery of lactylation opens up new avenues for research into other potential metabolic-driven PTMs, which also involve the intricate interplay of signaling pathways, PTMs, epigenetic mechanisms, and metabolic reprogramming. By further exploring the interconnections between metabolism and PTMs, researchers can gain crucial insights into the regulation of inflammation and develop more precise and effective treatments for a range of inflammatory conditions.
The goal of this Research Topic is to create a platform for discussing the latest advancements in understanding the mechanisms underlying inflammation in innate immunity, aims to explore how metabolic reprogramming influences posttranslational modifications and related alterations in signaling pathways and epigenetic mechanisms during the initiation and progression of inflammation. By gathering experts in the field, we seek to identify innovative therapeutic targets and strategies to modulate innate immune responses and ultimately mitigate the detrimental effects of acute or chronic inflammation on human health.
To deepen understanding in this dynamic field, we welcome submissions that explore a broad array of subtopics, including but not limited to:
- Phosphorylation, ubiquitination, and other posttranslational modifications in inflammation in innate immunity.
- Enzymes and therapeutic targets in posttranslational modifications in innate immunity
- DNA methylation and histone modifications in inflammation
- Role of non-coding RNAs in immune cells.
- Metabolic shifts and mechanisms in immune cells.
- Metabolic interventions to modulate inflammation.
- Metabolic reprogramming and posttranslational modifications as ovel therapeutic targets, preclinical evaluation, and combination therapy for immune diseases.
Keywords: metabolic reprogram
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
