The intestinal mucosal immune system is one of the largest and most complex components of the human immune system. Dysregulation within this system can lead to a range of gastrointestinal diseases. Intestinal inflammation plays a crucial role in disorders such as Helicobacter pylori-induced gastritis, eosinophilic gastroenteritis, inflammatory bowel disease (IBD), pancreatitis, and autoimmune hepatitis. Meanwhile, disruption of intestinal homeostasis can lead to immune imbalances and various liver diseases. The liver, as a critical frontline immune organ, processes gut-derived signals such as bacterial products and dietary antigens, maintaining a balance between immunity and tolerance. The prevalence and incidence of non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) continue to rise, exacerbating the burden of cirrhosis and liver cancer. Autoimmune liver diseases (AILDs) are also increasing epidemiologically, though their incidence remains relatively low in developing countries. Liver diseases remain among the top ten global causes of death.
As beneficial factors for health, bioactive compounds and nutrients play a key role in improving non-alcoholic fatty liver disease, cardiovascular disease, obesity, inflammatory bowel disease, and other diseases by regulating immunity. Bioactive compounds and nutrient interventions are widely accepted due to their safety and effectiveness.
This Research Topic aims to explore the impact of bioactive compounds and nutrients on intestinal mucosal immunity and liver health. It seeks to bridge the gap between nutritional science and immunology by highlighting the molecular mechanisms underlying these interactions and their implications for health and disease.
Focus areas include, but are not limited to:
1. Immunomodulatory effects and mechanisms of bioactive compounds and nutrients on intestinal immunity.
2. Immunomodulatory effects and mechanisms of bioactive compounds and nutrients in non-alcoholic fatty liver disease.
3. Metabolic characteristics and immune regulatory mechanisms of bioactive compounds and nutrients.
We invite submissions of high-quality original research articles, clinical studies, and reviews that contribute novel insights into the role of bioactive compounds and nutrients in host health.
Keywords: Bioactive compounds
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
