Exploring the Gut-Bone Axis: Microbial Regulatory Framework and Dynamics in Vertebrates

The intricate relationship between vertebrate bone health and the gastrointestinal microbiota represents a burgeoning field of research with profound implications for both welfare and economic outcomes. Recent studies indicate that key nutrients such as calcium, phosphorus, and vitamins are essential for bone development, calcification, and reconstruction, ultimately influencing the overall quality of human and animal products. Despite these advances, significant gaps remain in our understanding of the regulatory mechanisms underlying the gut-bone axis. Current research is beginning to shed light on how these interactions affect bone health, yet the complexity of these dynamics warrants deeper investigation to fully elucidate their impacts.

This research topic aims to enhance our understanding of the gut-bone axis' role in vertebrate bone health and its broader economic implications. Through exploring the molecular and biological interactions between gut microbiota and bone metabolism, the goal is to uncover novel regulatory mechanisms and natural compounds that positively influence bone quality and integrity.

To further investigate this complex interplay, we focus on both foundational and applied research concerning bone health in vertebrates. Research inquiries should critically assess:

o Regulatory factors within the gut-bone axis
o Nutritional impacts on bone growth and health

We welcome studies that address, but are not limited to, the following themes:

o The role of specific nutrients in bone development and health
o Mechanisms by which gut microbiota influence bone calcification and reconstruction
o Comparative analyses of bone health across different vertebrate species
o Effects of natural medicines and compounds on bone quality
o Economic analyses of bone health improvements on human and animal product quality

This structure allows for a systematic exploration of the complex relationships within the gut-bone axis, potentially leading to targeted strategies that improve vertebrate health and economic outcomes.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Case Report
• Clinical Trial
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Case Report
• Clinical Trial
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Policy and Practice Reviews
• Review
• Specialty Grand Challenge
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: Gut-bone axis, Microbiota, Osteoimmunology, Bone metabolism, Gut microbiome, Vertebrate physiology, Microbial-host interactions, Skeletal health, Bone density, Hormonal regulation

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.