Immuno-Pathological Mechanisms Driving Nasal Mucosal Symptoms in Long COVID

Long COVID has emerged as a significant global health concern. While the acute phase of the disease is well-documented, the persistent nasal symptoms experienced by many patients, including nasal congestion, rhinorrhea, anosmia, and ageusia, remain unclear. The development and persistence of these nasal symptoms are likely influenced by a combination of immunological and histopathological factors, as well as by potentially lingering viral replication or remnants.

This Research Topic aims to investigate the immunological and histopathological factors driving these symptoms. By exploring the interplay between host immune responses, viral remnants, and nasal tissue changes, this Research Topic seeks to advance our understanding of long COVID and inform effective diagnostic tools as well as potential therapeutic strategies.

To gather further insights, we welcome Original Research, Review and Brief Research Report articles addressing, but not limited to, the following themes:
- Immune Response Profiles in the nasal mucosa of long COVID patients, with a focus on understanding how immune dysregulation might drive persistent symptoms.
- Histopathological Changes in nasal tissues to uncover structural or cellular alterations that contribute to long-lasting symptoms.
- Role of viral persistence and remnants in the intensity and duration of symptoms.
- Potential biomarkers and therapeutic targets for prolonged nasal symptoms.