Decoding inflammation across diseases: Insights from omics technologies

Inflammation is a complex biological process that plays a key role in maintaining health and responding to infection or injury. However, dysregulated inflammatory responses are implicated in the progression of numerous diseases, including autoimmune disorders, cancer, cardiovascular conditions, and infectious diseases.

Advances in omics technologies, such as transcriptomics, proteomics, and epigenomics, have provided unprecedented opportunities to investigate the complex molecular mechanisms driving inflammation across diverse disease contexts.

By integrating multi-omics data, researchers can uncover novel regulatory pathways, identify key biomarkers, and develop targeted therapeutic strategies to modulate inflammatory processes effectively.

This Research Topic aims to address the critical gaps in our understanding of inflammation by leveraging cutting-edge omics technologies to explore its molecular underpinnings across various diseases.

While much progress has been made in dissecting inflammatory responses in isolated conditions, a comprehensive understanding of shared and unique mechanisms across different disease contexts remains elusive. This collection seeks to bridge this knowledge gap by fostering research that explores cell-specific responses, dynamic regulatory networks, and interactions between inflammatory pathways. By gathering contributions from diverse areas of expertise, we hope to advance the field by identifying actionable targets, highlighting emerging technologies, and paving the way for innovative therapeutic and diagnostic approaches.

This Research Topic investigates the role of inflammation in health and disease using advanced omics approaches. Specific themes include:

-Molecular pathways regulating inflammation across diseases

-Cell-specific and tissue-specific inflammatory responses

-Integration of multi-omics data to uncover regulatory networks

-Identification of biomarkers and therapeutic targets related to inflammation

-Emerging technologies and methodologies in omics-based inflammation research

We welcome studies that provide novel insights and foster innovation in the field of inflammation research. Submissions should aim to enhance our understanding of inflammatory processes and support collaborative efforts to uncover therapeutic and diagnostic opportunities across diverse disease contexts.

Please note that manuscripts consisting solely of bioinformatics or computational analysis of public omic databases which are not accompanied by robust and relevant validation, for instance in an independent patient population or by PCR, are considered out of scope of this section.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: Inflammation, Omics technologies, Immune regulation, Systems biology, Chronic diseases, Transcriptomics, Biomarker discovery

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.