Periodontal Disease and Systemic Health: Translational Insights and Clinical Approaches

Periodontal disease, an inflammatory condition of the oral cavity, not only affects oral health but also has a profound connection with systemic illnesses such as cardiovascular diseases, diabetes, respiratory conditions, and complications during pregnancy. Growing research has begun to illuminate the complex interrelationships between periodontal health and systemic diseases, suggesting that the effects extend far beyond the mouth. Despite significant advances, the specific molecular pathways and the nature of these connections remain insufficiently understood, requiring further investigation into how periodontal health impacts overall bodily health.

This Research Topic aims to delve into the intricate interactions between periodontal disease and systemic health conditions. By identifying the crucial inflammatory mediators and microbial interactions, the goal is to uncover how periodontal deterioration can influence, and be influenced by, various systemic diseases. This inquiry extends to the exploration of new diagnostic biomarkers and the effectiveness of periodontal interventions on broader health outcomes, providing a dual perspective that bridges the gap between dental and systemic health treatments.

To gain deeper insights into the interplay between oral and systemic health, this Research Topic will cover a spectrum of related themes. We welcome submissions that focus on, but are not limited to, the following areas:
- Inflammatory and immune mechanisms linking periodontal and systemic health
- The role of the oral microbiome in systemic diseases

This Research Topic encourages a variety of article types, including original research, comprehensive reviews, clinical trials, and case studies, all aimed at enhancing our understanding and management of the nexus between dental and systemic health. Through this focused exploration, we aim to foster a more integrated approach to health care, promoting better patient outcomes across disciplines.

Keywords: Periodontal-Systemic Health; Oral- Systemic Disease; Inflammatory Pathways, Cardiovascular Disease; Oral Microbiome, Immune-Modulation; Diabetes Mellitus; Rheumatoid Arthritis; Pregnancy Outcomes; Periodontal Therapy

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.