Endometrial Health and Disease: From Molecular Insights to Clinical Advances

The endometrium plays a crucial role in reproductive success across animal species, undergoing dynamic changes in response to hormonal cues. Disruptions in endometrial function can lead to infertility, pregnancy loss, and other reproductive disorders in both domestic and wild species. Recent advances in molecular biology, genomics, and reproductive biotechnology have provided deeper insights into the mechanisms regulating endometrial health and disease. In livestock, conditions such as endometritis and subclinical infections impact fertility and productivity, while in companion and wildlife species, reproductive disorders pose conservation and welfare challenges. This Research Topic explores the latest research on endometrial physiology, pathology, and therapeutic interventions across diverse animal models, bridging the gap between fundamental science and clinical applications. By integrating molecular and translational approaches, we aim to advance knowledge that can improve reproductive outcomes in veterinary medicine and animal breeding.

The goal of this Research Topic is to highlight recent advancements in understanding endometrial health and disease across animal species, integrating molecular, cellular, and clinical perspectives. By bringing together cutting-edge research, this collection aims to explore key aspects of endometrial biology, including molecular signalling pathways, immunological responses, microbiome interactions, and novel diagnostic and therapeutic strategies. A special focus will be given to translational approaches that bridge fundamental research with clinical applications in veterinary medicine and animal breeding. Studies utilizing in vivo, in vitro, and omics-based methodologies are encouraged. Ultimately, this collection seeks to advance knowledge that can enhance reproductive efficiency, improve disease management, and contribute to animal health and conservation efforts.

We welcome original research, reviews, and short communications that provide novel insights into endometrial function, diagnostics, and therapeutics across diverse species. Specific themes include:

- Endometrial physiology and hormonal regulation

- Molecular and cellular mechanisms of endometrial function

- Endometritis and other reproductive disorders in domestic animals

- Microbiome and immune interactions in the endometrium

- Impact of infections and environmental factors on endometrial health

- Omics approaches (genomics, proteomics, metabolomics)

- Novel diagnostic biomarkers and imaging techniques

- Translational research and therapeutic innovations

Authors should follow the journal’s guidelines for manuscript preparation and submission.

Keywords: endometrium, female, disease, endometrium physiology, reproduction, endometrial disease

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.