The field of metabolic and endocrine diseases, notably diabetes, obesity, MAFLD, and thyroid disorders, is undergoing significant scrutiny as these conditions escalate globally and impose substantial public health burdens. Blood lipids, including cholesterol (such as HDL-C and LDL-C) and triglycerides, are fundamental to cardiovascular and metabolic health. While normal lipid levels contribute to cell membrane integrity, hormone synthesis, and energy balance, deviations in these levels are linked to various metabolic and cardiovascular diseases. This juxtaposition of the essential role of lipids at normal levels versus their detrimental effects when abnormal underscores the critical need for further research into their precise mechanisms and impacts.
Research is increasingly focused on elucidating how normal lipid levels can mitigate risks associated with metabolic dysfunctions like atherosclerosis, insulin resistance, and enhanced inflammatory responses. Initiatives to maintain lipid levels within a healthy range through diet, exercise, and medication underscore their importance in disease prevention strategies. However, there remains a substantial gap in understanding the specific regulatory mechanisms by which normal lipid levels exert their protective effects in metabolic health, warranting deeper investigation.
This Research Topic aims to explore the role of normal blood lipid levels by investigating the dose-response relationship between normal blood lipid levels and the risk of metabolic and endocrine diseases. Recent advances in lipidomics, genetic studies, and large-scale cohort analyses provide new tools to explore these associations in greater detail. By leveraging these technologies, researchers can identify precise lipid thresholds and biomarkers that predict disease risk even within the normal range. Ultimately, this topic will provide evidence-based guidelines for clinicians to tailor lipid management strategies, potentially reducing the burden of metabolic and endocrine diseases on healthcare systems.
To gather further insights, we invite submissions of Reviews, Original Research, and Systematic Reviews, focusing on mechanisms, clinical implications, and therapies related to normal lipid levels in metabolic health. Potential topics include, but are not limited to:
o Dose-response relationships between normal blood lipid levels and metabolic disease risk.
o The impact of normal lipid levels on insulin sensitivity and glucose metabolism.
o Identification of biomarkers and diagnostic tools for assessing lipid levels in metabolic health.
o The anti-inflammatory effects of optimal lipid levels in metabolic diseases.
o Lifestyle and pharmacological interventions for maintaining healthy lipid profiles.
Keywords: Normal blood lipid levels, metabolic diseases, endocrine diseases, risk factor
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
